Drug Discovery Featured Articles & Applications

  1. How Atsena Got Its Gene Therapy To Spread Subretinally To Treat XLRS 12/6/2024

    The company’s novel capsid, part of a Phase 1/2 trial, is delivering therapeutic genes to the fovea without the need for detaching part of the retina.

  2. 2024 Survey Findings: How Is The "Lab Of The Future" Becoming Reality? 12/3/2024

    The Pistoia Alliance conducted a survey as a pulse check on which technologies the pharma/biotech industry is investing in and companies' progress integrating new tech into the lab.

  3. Seeing Firsthand The Transformative Impact Of AI On Pharmacovigilance And Clinical Research 11/27/2024

    Consultants Aashna Goyal and Guriqbal Singh share first-persona accounts of how AI is transforming pharmacovigilance and clinical research by improving data processing, enhancing decision-making, and accelerating drug development.

  4. Should We Explore Suicidality In Animals During Preclinical Drug Development? 11/19/2024

    An adverse side effect for some drugs is suicidal ideation and behavior (SIB). Investigating SIB in animal studies represents the closest approximation to human SIB, yet the FDA Modernization Act 3.0 obligates us to reduce unnecessary animal testing. Let's examine this with data-driven research.

  5. How To Overcome Immune Rejection In iPSC-based Gene Therapy 11/6/2024

    Even when induced pluripotent stem cells (iPSCs) are derived from the patient's cells, immune rejection can still occur. This article explores the causes as well as strategies to overcome immune rejection.

  6. Emerging Partnership Trends In Oligo-Based Medicines 11/6/2024

    The oligonucleotides sector is quickly evolving and seeing more industry partnerships than ever before. We caught up with DeciBio's Carl Schoellhammer and Phillip Leclair for their analysis.

  7. Exploring Sanofi R&D's Batch Monitoring Initiative 10/23/2024

    The project established predictability during testing and release for the production of medicine to support clinical trials.

  8. Panavance Details IND Prep Ahead Of FDA Submission For Ovarian Cancer Trial 10/23/2024

    Panavance CEO Greg Bosch discusses the company’s pursuit of a second trial for misetionamide, walking us through IND preparations, CRO selection, and securing funding. 

  9. iPSC-based Gene Therapy: Applications And Challenges 10/15/2024

    Induced pluripotent stem cells (iPSCs) are generated by reprogramming adult somatic cells into a pluripotent state, meaning they can develop into any cell type in the human body. This has tremendous potential in regenerative medicine and gene therapy.

  10. Restoring Immune Homeostasis As A Development Approach To Treat And Modify Inflammatory Disease 10/8/2024

    Drawing from experiences with ongoing work at AnaptysBio, Inc., senior VP of research Martin Dahl, Ph.D., shares three considerations when developing immune cell modulators to treat and modify inflammatory disease.