Drug Discovery Featured Articles & Applications

41. CRISPR-Cas Genome Editing For Rejuvenation Of Aging Stem Cells 7/1/2024

    As stem cells age, their regenerative capacity declines due to accumulated genetic and epigenetic changes. Using CRISPR-Cas, scientists can directly edit these changes or modulate aging-related pathways.

42. Cell Therapies For Solid Tumors: Optimizing Your Approach To Achieve Regulatory Approval 6/19/2024

    Developing and ultimately obtaining approval of cell therapies for solid tumors requires an organized and scientifically rigorous approach. This article is a helpful road map of considerations.

43. Where's The Case For Generative AI In Biopharmaceutical Manufacturing? 6/12/2024

    The early use cases for AI in the biopharmaceutical industry—at least, the early public use cases—have largely come from R&D, and more specifically, target identification and molecular design. Where are the use cases in biologics manufacturing, supply chain management, QMS, and operations, and what’s holding us back?

44. Periodontitis And Neurological Disease: New Insights For Drug Targeting 6/10/2024

    This article discusses the link between periodontal disease and systemic disorders, focusing most on the association between proteases and neurological dysfunction. Therapeutic measures can target these pathological pathways.

45. Beware AI Hallucinations 6/7/2024

    As the use of AI increases and expands to new functional areas within biopharmaceutical companies, leaders must understand the risks and mitigate the impact of hallucinations in AI model outputs.

46. Is Your Intellectual Property Safe With Indian CROs And CDMOs? 6/3/2024

    Startups and Big Pharma companies alike are considering India as an alternative to working with China. Is it safe to do business with India? Let's do a deep dive, with insights from American and Indian attorneys.

47. Revolutionizing Modifier Gene Therapy Through A Gene-Agnostic Approach 5/29/2024

    Traditional methods reliant on individual gene replacement strategies have limitations. Researchers are now investigating ways to use a single modifier gene to treat an array of diseases.

48. FDA's Draft Guidance On Safety Testing Of Human Allogeneic Cells For Use In Cell-Based Therapies 5/24/2024

    This article provides a summary and analysis of the FDA's new draft guidance, Safety Testing of Human Allogeneic Cells Expanded for Use in Cell-Based Medical Products. The public comment period ends July 29.

49. Cannabinoids Show Promise As New Treatment For Alzheimer's Disease 5/18/2024

    Cannabinoids and their innate interaction with the endocannabinoid system, specifically with neuronal functioning, present an attractive therapeutic pathway for Alzheimer's disease, explains Eric Hsu, Ph.D., senior vice president of preclinical research and development at InMed Pharmaceuticals. 

50. Gene Therapy: How Should We Approach Benefit And Risk? 5/14/2024

    Understanding the benefit-risk ratio is a complex exercise for gene therapies, where there hasn't been sufficient time to understand the long-term risks. How should we approach it?