Drug Discovery Featured Articles & Applications

  1. CAR T-Cell Therapy: The Road Ahead

    In recent years, we have witnessed a meteoric rise in clinical studies of cancer immunotherapies, catapulting immuno-oncology into one of the fastest growing and dynamic areas in pharmaceutical development today.

  2. Single-Use vs Stainless: An Economic Microbial Fermentation Comparison

    In this case study, we compare production capacity and process economy between stainless steel and single-use equipment in microbial processes. Economy simulations were based on an E. coli Dab process. Production scenarios in both single- and multi-product facilities were considered.

  3. Crystalomics: A Pathway Forward For Protein Crystallization

    Protein crystals have shown the potential to address many of the issues associated with high concentration/high viscosity solutions. While formulation and delivery challenges exist with crystallized formulations, they are not insurmountable. With access to the right level of expertise and experience, a company can manufacture its product using crystallization, thereby increasing patient compliance by offering an easier and faster form of drug delivery. 

  4. Is your Complex Formulation Process Set Up for Success?

    This article discusses six major types of complex formulations as well as the important equipment and processes necessary to develop GMP-compliant processes.

  5. Development And Validation Of Human Chemokine Assays

    The chemokine system belongs to a large family of inflammatory cytokines and receptors. Approximately 50 chemokines and 20 receptors have been identified and shown to play a critical role in tumor growth, inflammatory response, infection, autoimmune disorders, neoplasm, vascular diseases, and transplant rejection (Locati et al. 2005, Slettenaar and Wilson 2006).

  6. Inaccurate Forecasting Is Here To Stay: Focus On Managing Risk Instead

    The single most important factor influencing pharmaceutical and biopharmaceutical decisions is demand forecasting. Forecasts impact decisions regarding capital cost, outsourcing for product commercialization, and many other critical aspects of production. It’s no secret that drug forecasts are notoriously incorrect, and often by large margins. John LaMattina, former president of Pfizer Global R&D, foresees no improvement in forecasting accuracy. How then, do companies minimize risk?

  7. The Right Biomanufacturing Partner Can Improve Flexibility And Mitigate Risks From Forecasting

    While forecasts can never be 100% accurate, the goal for biopharmaceutical forecasters should be to minimize the degree of inaccuracies as much as possible. To reduce the impact of inaccurate forecasting over the life cycle of a product, companies need to focus on those variables that they have the most control over.

  8. Challenges, Risks And Strategies For Biologic Substance Manufacturing

    From discussions with pharmaceutical and biotechnology industry leaders, it is clear that demand forecasting is a significant challenge when planning biologic drug substance production.

  9. Brexit’s Impact On The Global Pharmaceutical Industry: Market Authorization & Pricing

    The Brexit referendum has resulted in instability and uncertainty for many aspects of British society, including the pharmaceutical industry. As we discussed in Part 1 of this two-part article, life sciences funding and the common market are at risk, and with it billions of dollars in research funding and imports/exports. In this article, we will explore the UK’s future relationship with the EU after exit, which will affect many facets of the worldwide pharmaceutical industry, from marketing authorization to global pricing trends.

  10. It’s Time To Go Electronic In The Lab – Infographic

    The paper-based lab versus the digital lab. The largest barrier to innovation for any lab is performing tasks manually and recording experiment data in paper lab notebooks. Easy-to-use digital applications can increase productivity while reducing wasted time and inefficiencies associated with searching for relevant experiment data.