Drug Discovery Featured Articles & Applications

  1. Tracking 4 Payload Trends In Drug Delivery Development 1/22/2024

    Amid new research and development in nanocarriers, market attention has shifted toward payloads and enhancing compatibility. This discussion explores the latest trends and includes a research database.

  2. Understanding Undruggable Targets: Challenges And Progress 1/18/2024

    As we continue to discover new treatment approaches, we need to go beyond targeting proteins with well-defined pockets and find other ways to target the undruggable. Two approaches that show promise are PROTACs and molecular glues.

  3. The Benefits Of Using GenAI In Drug Discovery And Preclinical Development 1/17/2024

    The emergence of generative artificial intelligence (GenAI) has the potential to reform early-stage drug discovery and development. Large language models are being harnessed to create novel molecules tailored for specific properties, positioning them as potential drug candidates. It could also unveil previously overlooked therapeutic possibilities. Pharma leaders must ensure they have a sound strategy for this.

  4. Finding New Treatments In Old Therapies 1/12/2024

    Discover the types of repurposed drugs and tips for making them a reality with international healthcare consultant Robert L. Quigley, MD, D.Phil.

  5. A Patient-Centric Approach Built On The Porosome 1/10/2024

    About 85% of disease-causing proteins remain impervious to current therapeutic interventions. One potential pathway to address this problem is the structure in the cell that constitutes its secretory machinery: the porosome.

  6. Animal Testing Isn't Perfect. Is There An Alternative? 1/8/2024

    Statistics have been showing that rodent and non-rodent experiments predict human toxicity in only 48-71% of drugs. The FDA Modernization Act 2.0 of 2022 permits the use of suitable animal-free new approach methodologies, and the European Parliament launched a program to eliminate animal studies "as soon as scientifically possible." Let's take a data-driven, research-driven look at the topic.

  7. AI In Drug Discovery And Development — Will It Live Up To The Hype? 1/5/2024

    While AI may soon transform the drug discovery and development process, there are still several barriers, both technical and ethical, to the rise of AI in biopharma.

  8. AI's Role In Drug Discovery To Propel Personalized, Patient-Centric Medicine 12/20/2023

    AI-driven drug discovery and development represents a future where new medicines could become more precise and effective, better tolerated, and better tailored to an individual. This article shares an overview of how AI can help in this, and how can we work in a more active way toward this future.

  9. 4 Strategies To Formulate Poorly Soluble APIs 12/18/2023

    One of the toughest challenges facing small molecule drug development today is poor solubility of the API. No single technique has universal application, so several strategies exist. This article examines four notable strategies.

  10. WHO's 6 Principles For An AI Regulatory Framework For Medical Product Development 12/14/2023

    In mid-Oct. 2023, the WHO published a paper titled Regulatory Considerations on Artificial Intelligence for Health, identifying the key principles that international regulatory frameworks for artificial intelligence (AI) should address and are, in fact, starting to coalesce around. The paper was developed in consultation with a WHO Working Group whose members include regulatory authorities, policy makers, and more.