Drug Discovery Featured Articles & Applications

  1. Medium Preparation For Single-Use Fermentation

    Single‑use fermenters are becoming an increasingly viable alternative to stainless steel, offering less time is spent on equipment preparation and qualification prior to start-up as well as routine maintenance and requalification of the equipment.

  2. Single-Use Stirred Tank Fermentor System Performance Comparison

    The process design proven for one fermentor system is not always directly transferrable to other system formats without adaptation. Here, we compare the performance of the XDR‑500 MO fermentor with the XDR‑50 MO system.

  3. Roivant Sciences Accelerates Process Development To Speed Orphan Therapy To Market

    This case study shares the work of GE’s Fast Trak Services team to help accelerate development of a process for cGMP production of material for toxicology studies.

  4. Single-Use Workflow For Recovery Of A Domain Antibody From E. Coli Culture Feed In An Automated Manner

    This application note demonstrates the performance of the automated ÄKTA™ readyflux single-use filtration system in microfiltration applications. 

  5. Automated Ultrafiltration/Diafiltration Results With Minimized Hands-on Time

    This work describes the capabilities of ÄKTA readyflux when used in ultrafiltration/diafiltration (UF/DF) applications. The process was conducted in an automated manner based on methods created using phases predefined in the UNICORN™ system control software.

  6. Understanding Biomarkers For Better Drug Discovery And Development

    In collaboration with Amplion Inc., we investigated biomarker usage within 24 companies focused on immunotherapy. This article shares exciting insights from our analysis, including which biomarkers are the most popular and how those biomarkers are being utilized by each company.

  7. Let The Molecule Decide

    Formulation techniques and technologies can easily become more habit than science, but a single technology does not work for all compounds. Each new drug is unique and deserves a fresh approach to formulation.

  8. The Race to Phase III: A Cautionary Tale of Scalability

    Follow the paths of two companies as they learn how a science-led, risk-based development approach yields a more successful outcome in the long run.

  9. Achieving Optimal mAb Titer and Quality Through Cell Culture Media and Supplement Optimization

    In addition to having the optimal cell line and process, it is crucial to have the optimal cell culture medium and feed to maximize  performance potential.

  10. Optimizing Titer and Use of a Specific Enzyme for Generating a Fully Processed Antibody

    An outline of the cell development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct functionality.