FEATURED EDITORIAL
The hope is that AI can solve the single most challenging problem at the heart of modern drug discovery: the reliable prediction of novel small molecule drugs that potently bind to a disease-causing protein and alter its function. This article discusses the challenges and how we can position ourselves to navigate them.
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FEATURED APPLICATION CONTENT
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This article presents a case study that explores the material and performance properties of spray-dried and jet-milled mannitol for respiratory delivery of crystalline mannitol.
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Here, electron activated dissociation (EAD) on the ZenoTOF 7600 system is used for the complete structural elucidation of glycerophospholipids, sphingolipids, and acylglycerols in a single experiment.
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Fragmentation is required to provide structural information about metabolites during drug discovery. Here, two orthogonal fragmentation techniques are compared to determine the in vitro metabolism of the drug darunavir.
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Post-translational modifications (PTMs) are important players in a diverse group of functions that include protein conformation and signaling. This application note studies the site-localization of malonylated peptides using the SCIEX ZenoTOF 7600 system.
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In this technical note, we demonstrate parallel, highly reproducible capillary isoelectric focusing analysis using a multi-capillary separation approach to accelerate analysis time.
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In this scientific brief we evaluate the performance of the the Pall Nucleic acid binding (NAB) Nanosep centrifugal device for nucleic acid isolation.
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In this report, we analyze the quality and quantity of gDNA as well as RNA from S. cerevisiae with Pall NAB Nanosep centrifugal devices in comparison with a renowned commercial brand.
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How Syringe Filtration With Integrated Prefilter Technology Improves HPLC Performance And Throughput
In this article we review how particulate removal through filtration effects column life and how to handle difficult to filter samples.
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We examine whether the sample tubes and collection tubes of the NAB Nanosep centrifugal devices contain detectable amounts of DNase or RNase.
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This scientific brief reviews how high-performance syringe filters protect and extend the life of analytical HPLC and UHPLC instruments and columns.
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This study assesses the use of NAB Nanosep centrifugal devices with commercially available reagents for PCR or agarose gel cleanup.
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This paper simplifies syringe filter selection and reviews the membranes and sizes required for specific analytical applications.
FEATURED NEWS HEADLINES
- Altesa BioSciences Recognizes Co-Founder And Partner For Major NIH Research Grant To Discover New Antiviral Drugs
- Excelra Partners With Hotspot Therapeutics To Enhance Allosteric Drug Discovery Efforts
- Galapagos In-Licenses Novel Drug Targets For Inflammatory Bowel Disease Discovered By Scipher Medicine’s Spectra Platform
- Noveome Biotherapeutics, Inc. Receives Rare Pediatric Disease Designation And Orphan Drug Designation For The Treatment Of Necrotizing Enterocolitis In Neonates
- Ceruvia Lifesciences Submits FDA Investigational New Drug Application For Psilocybin Obsessive-Compulsive Disorder Program
- Research Boosts 'Game-Changing' Technology To Strengthen Drug Development
- U Of M Receives NIAID Grant To Develop Drug Treatments For Future Viral Pandemics
- TherapeuticsMD Receives U.S. Food And Drug Administration (FDA) Approval For Supplemental New Drug Application (sNDA) For ANNOVERA
- Almac Discovery And Hitgen Announce Strategic Research Collaboration
- New Study Shows Genes Can Predict Response To Arthritis Treatment And Paves The Way For Future Drug Development
ARCHIVED NEWSLETTER
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- 05.17.22 -- Take Control Of And Optimize Your Development Process