FEATURED APPLICATION CONTENT

• Delivering Pre-IND To IND Safety Studies In Just Three Months

  A biotech company partnered with an integrated research, development and manufacturing services company to deliver pre-IND to IND safety studies for a treatment therapy for gut-brain diseases.

• Capture Of Bispecific Antibodies And Removal Of Product-Related Impurities

  Many antibody variants are prone to aggregation or to forming product-related impurities. Explore the application of a resin with novel selectivity to purify challenging entities.

• Successful Filter Integrity Testing Using The WIT Method

  Explore the collected best methods/practices to give filter end users the best possible chance of performing a successful water intrusion test.

• Generating A Robust Host Cell Line For A Cell Line Development Platform

  Learn how cell performance within the context of the cell line development workflow was confirmed with the successful isolation of stable, high-producing clones from three model monoclonal antibodies.

• Biacore™ SPR Systems For Titer Analysis Of Adeno-Associated Virus

  We describe the performance of two assays for titer analysis of adeno-associated virus (AAV), serotype 2 and serotype 5, based on surface plasmon resonance (SPR).

• AAV Production In Suspension HEK293 Cells With Single-Use Bioreactors

  Explore how we expanded HEK293/HEK293T suspension cells from small cell culture (20 mL) in shake flasks up to a 10 L culture in a benchtop Xcellerex™ XDR-10 single-use bioreactor system.

• Recombinant Adeno-Associated Virus Type 5 Production Process

  Learn about a scalable process for the production of rAAV using triple plasmid transfection of suspension cells in an animal-derived component-free medium.

• Systems For Shop Floor Automation And Digitization

  We review an automation system that is based on a standard technology platform, with standardized hardware, networking, and software elements and is designed to securely connect to end-user networks.

• Cybersecurity And Product Design Of Automated Systems

  Learn about the importance of cybersecurity for automated equipment, it's weaknesses and risks, and how to mitigate for them by sensible practice and good system design.

• The Power Of Modular Design

  Learn how modular design has the potential to provide a solution for the increasing pressure and demand for biologics.

• BioPharma Expands 3D Structure Portal

  Learn about the competitive advantage that helped a research-based biopharmaceutical company close the communication gap between medicinal chemists and modelers.

• Smart Data For Smart Decisions

  Learn how quality of data directly impacts decision-making efforts along with factors to ensure smart data and the value of an open and flexible integration platform.