FEATURED APPLICATION CONTENT

• Differentiation Of Leucine And Isoleucine Using Electron Activated Dissociation (EAD)

  We demonstrate the combination of routine characterization and elucidation of challenging residues in one single analysis, without the need for sample specific optimization.

• Comprehensive Peptide Mapping Of Biopharmaceuticals Utilizing Electron Activated Dissociation (EAD)

  We demonstrate in-depth peptide mapping of new and complex molecules, as well as standard monoclonal antibodies (mAb), that can be achieved with this system in a fully automated fashion.

• Precision Powder-In-Capsule Micro-Dosing Accelerates Drug Product Development

  Precision powder microdosing makes it possible to quickly get formulations to the clinic, saving time, money, and use of limited APIs.

• Integrated First-In-Human Services To Streamline End-To-End Development And Manufacturing

  Lonza’s SimpliFiH^®️ Solutions offering is designed to simplify and accelerate the development pathway, even for APIs with challenging properties, such as low aqueous solubility and poor bioavailability.

• Engineering Approaches To Respiratory Drug Delivery: Mannitol Case Study

  This article presents a case study that explores the material and performance properties of spray-dried and jet-milled mannitol for respiratory delivery of crystalline mannitol.

• Complete Structural Elucidation Of Lipids In A Single Experiment Using Electron Activated Dissociation (EAD)

  Here, electron activated dissociation (EAD) on the ZenoTOF 7600 system is used for the complete structural elucidation of glycerophospholipids, sphingolipids, and acylglycerols in a single experiment.

• Orthogonal Fragmentation Mechanism Enables New Levels Of Metabolite Characterization

  Fragmentation is required to provide structural information about metabolites during drug discovery. Here, two orthogonal fragmentation techniques are compared to determine the in vitro metabolism of the drug darunavir.

• Preserve Particularly Labile Post-Translational Modifications

  This application note studies the site-localization of malonylated peptides using the SCIEX ZenoTOF 7600 system.

• High-Throughput Characterization Of RNA

  Here we demonstrate how a multi-capillary capillary electrophoresis (CE) system is used to efficiently separate a wide range of RNA-based molecules by size and demonstrates the multiplex capability for RNA characterization.

• Parallel Processing Of Charge Heterogeneity Analysis Of Protein Therapeutics

  In this technical note, we demonstrate parallel, highly reproducible capillary isoelectric focusing analysis using a multi-capillary separation approach to accelerate analysis time.

• Acceleration Of Method Optimization For AAV Capsid Purity Analysis Using Multi-Capillary Electrophoresis Platform

  We highlight how a multi-parameter approach using CE-SDS with laser-induced fluorescence detection (LIF) can significantly expedite methods development and optimization of AAV capsid purity analysis.

• Ensure High Quantity And Quality Of Isolated Bacterial Ribonucleic Acid (RNA)

  In this scientific brief we evaluate the performance of the the Pall Nucleic acid binding (NAB) Nanosep centrifugal device for nucleic acid isolation.