FEATURED APPLICATION CONTENT

• Process Control And Performance Of A Depth Filtration System

  Explore a demonstration of strategic process control in terms of flow and pressure, by utilizing a depth filtration system, for effective depth filter processing and recovery of excess product.

• rAAV Production Using HEK293 Cell Line And Transfection Medium

  Learn more about improving the performance of a scalable AAV process in Xcellerex™ XDR-10 and XDR-200 bioreactors using HyClone™ peak expression medium.

• Establishing A Robust Workflow To Identify High-Performing Clones

  Cell line development is a complex, labor intensive, and multistep process. Learn about a platform and host cell line that minimize the risk and timeline to develop high-performing clones.

• Process Control And Performance Of A Virus Filtration System

  Discover a single-use automated filtration system designed to deliver robust process control and integrity assurance during the critical purification step. Explore its innovative design features, processing control, and more.

• Maximize Product Recovery In Bulk Filtration And Filling Flow Paths

  Explore a fill system designed to automate product draining and recovery within a batch to standardize processes and minimize non-recoverable hold-up within the filtration and distribution flow path sections.

• A Versatile Method For Capsule And Depth Filtration

  Learn about a solution that can provide a simple, easy, and versatile method for capsule and depth filtration, allowing a quick, efficient move from cell harvest to purification.

• Delivering Pre-IND To IND Safety Studies In Just Three Months

  A biotech company partnered with an integrated research, development and manufacturing services company to deliver pre-IND to IND safety studies for a treatment therapy for gut-brain diseases.

• Capture Of Bispecific Antibodies And Removal Of Product-Related Impurities

  Many antibody variants are prone to aggregation or to forming product-related impurities. Explore the application of a resin with novel selectivity to purify challenging entities.

• Successful Filter Integrity Testing Using The WIT Method

  Explore the collected best methods/practices to give filter end users the best possible chance of performing a successful water intrusion test.

• Generating A Robust Host Cell Line For A Cell Line Development Platform

  Learn how cell performance within the context of the cell line development workflow was confirmed with the successful isolation of stable, high-producing clones from three model monoclonal antibodies.

• Biacore™ SPR Systems For Titer Analysis Of Adeno-Associated Virus

  We describe the performance of two assays for titer analysis of adeno-associated virus (AAV), serotype 2 and serotype 5, based on surface plasmon resonance (SPR).

• AAV Production In Suspension HEK293 Cells With Single-Use Bioreactors

  Explore how we expanded HEK293/HEK293T suspension cells from small cell culture (20 mL) in shake flasks up to a 10 L culture in a benchtop Xcellerex™ XDR-10 single-use bioreactor system.