The ADC field is in a transitional period. Older approaches to conjugate composition and dosing regimens still dominate the ADC clinical pipeline, but preclinical work is driving a rapid evolution in how we strategize to improve efficacy and reduce toxicity towards better therapeutic outcomes. In an indication of future directions for the field, antibody conjugates bearing non-cytotoxic small molecule payloads are being developed to reduce side effects associated with treatment of chronic diseases.
The importance of optimizing the chemical synthesis and formulation processes in complex molecule development.
Learn how a structured 3-step approach can help overcome the challenge of molecular characterization and a limited budget.
Smart bioprocessing uses bioinformatics, lab-scale processing, and analytics to create efficient and cost-effective production processes that can be verified at lab-scale before scale-up.
Read how this method resulted in higher purity and yield than what can be expected from a purification process based on salt precipitations and sucrose gradient centrifugation.
See how a combination of Biacore instruments, software, sensor chips, and kits supports the setup of screening and characterization assays and reduces assay development efforts.
Examples of how label-free biophysical binding assays are successfully employed in all steps in the immunogenicity workflow to ensure confident detection, confirmation, and comprehensive characterization of immune responses.
Review the use of Biacore for active concentration measurements, target binding, and Fc receptor (FcR) analysis along with the use of these assays for assessment of drug potency and stability.
This application note describes how to achieve accurate comparability assessments using Biacore™ T200 and Amersham™ WB system in the development of a biosimilar.
This white paper presents fundamentals about analytical SEC and describes how our new-generation agarose-based SEC columns are used in analysis of biomolecules.
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