Drug Discovery Featured Articles & Applications

  1. The Unique Needs Of The HPAPI Market: Are You Prepared?
    11/22/2017

    To take advantage of the growing HPAPI market, a company must have the proper controls in place to safely handle these potent compounds and successfully bring its drug to market.

  2. Are You Prepared For The Complexity Of Pediatric Drug Development?
    11/22/2017

    Pediatric drug development requires a formulation designed to fit the specific needs of that patient population. Not considering these requirements early enough could add significant delays.

  3. Medium Preparation For Single-Use Fermentation
    11/17/2017

    Single‑use fermenters are becoming an increasingly viable alternative to stainless steel, offering less time is spent on equipment preparation and qualification prior to start-up as well as routine maintenance and requalification of the equipment.

  4. Single-Use Stirred Tank Fermentor System Performance Comparison
    11/17/2017

    The process design proven for one fermentor system is not always directly transferrable to other system formats without adaptation. Here, we compare the performance of the XDR‑500 MO fermentor with the XDR‑50 MO system.

  5. Roivant Sciences Accelerates Process Development To Speed Orphan Therapy To Market
    11/10/2017

    This case study shares the work of GE’s Fast Trak Services team to help accelerate development of a process for cGMP production of material for toxicology studies.

  6. Single-Use Workflow For Recovery Of A Domain Antibody From E. Coli Culture Feed In An Automated Manner
    11/3/2017

    This application note demonstrates the performance of the automated ÄKTA™ readyflux single-use filtration system in microfiltration applications. 

  7. Automated Ultrafiltration/Diafiltration Results With Minimized Hands-on Time
    11/3/2017

    This work describes the capabilities of ÄKTA readyflux when used in ultrafiltration/diafiltration (UF/DF) applications. The process was conducted in an automated manner based on methods created using phases predefined in the UNICORN™ system control software.

  8. Understanding Biomarkers For Better Drug Discovery And Development
    11/2/2017

    In collaboration with Amplion Inc., we investigated biomarker usage within 24 companies focused on immunotherapy. This article shares exciting insights from our analysis, including which biomarkers are the most popular and how those biomarkers are being utilized by each company.

  9. Let The Molecule Decide
    11/2/2017

    Formulation techniques and technologies can easily become more habit than science, but a single technology does not work for all compounds. Each new drug is unique and deserves a fresh approach to formulation.

  10. The Race to Phase III: A Cautionary Tale of Scalability
    10/30/2017

    Follow the paths of two companies as they learn how a science-led, risk-based development approach yields a more successful outcome in the long run.