Drug Discovery Featured Articles & Applications

51. Bridge RNAs: Principles, Applications, And Challenges 8/1/2024

    Bridge RNAs are structured noncoding RNAs that facilitate programmable recombination between target and donor DNA, enabling precise genomic rearrangements. A significant advantage is their modularity.

52. Is Your Lab Ready For A LIMS Implementation? 7/25/2024

    Deploying a laboratory information management system (LIMS) can boost your quality control lab's productivity, but how are you going about it? This article shares key steps and considerations for setting up your physical lab, controlling inventory, and more.

53. Correct But Misleading: AI Hallucinations In Complex Decision-Making 7/11/2024

    Managing risks associated with AI hallucinations requires "explainability," a process that identifies patterns or behaviors in AI models that are inconsistent with training data or logical expectations. Regulators are mandating transparency in AI models used for drug testing and development.

54. Harnessing The Power Of the Innate Immune System In Cancer Research 7/9/2024

    The body’s innate immune system — natural killer cells in particular — has emerged as a promising avenue for cancer researchers.

55. ChatGPT-4: Practical Applications For The Biopharma Laboratory 7/3/2024

    AI has made its way into the biopharma laboratory, and ChatGPT-4 is the most popular. Do you know the capabilities that this tech can deliver?

56. Discovering "Molecular Hallmarks" And "Master Regulators" In Epilepsy 7/2/2024

    As we look into the future, understanding the molecular hallmarks of epilepsies will be vital, and insights into the genetics and disease pathways will play a key role. The expert also discusses some of UCB's work in this area.

57. CRISPR-Cas Genome Editing For Rejuvenation Of Aging Stem Cells 7/1/2024

    As stem cells age, their regenerative capacity declines due to accumulated genetic and epigenetic changes. Using CRISPR-Cas, scientists can directly edit these changes or modulate aging-related pathways.

58. Cell Therapies For Solid Tumors: Optimizing Your Approach To Achieve Regulatory Approval 6/19/2024

    Developing and ultimately obtaining approval of cell therapies for solid tumors requires an organized and scientifically rigorous approach. This article is a helpful road map of considerations.

59. Where's The Case For Generative AI In Biopharmaceutical Manufacturing? 6/12/2024

    The early use cases for AI in the biopharmaceutical industry—at least, the early public use cases—have largely come from R&D, and more specifically, target identification and molecular design. Where are the use cases in biologics manufacturing, supply chain management, QMS, and operations, and what’s holding us back?

60. Periodontitis And Neurological Disease: New Insights For Drug Targeting 6/10/2024

    This article discusses the link between periodontal disease and systemic disorders, focusing most on the association between proteases and neurological dysfunction. Therapeutic measures can target these pathological pathways.