Drug Discovery App CS WP
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Precision Powder-In-Capsule Micro-Dosing Accelerates Drug Product Development
6/1/2022
Precision powder microdosing makes it possible to quickly get formulations to the clinic, saving time, money, and use of limited APIs.
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Integrated First-In-Human Services To Streamline End-To-End Development And Manufacturing
6/1/2022
Lonza’s SimpliFiH®️ Solutions offering is designed to simplify and accelerate the development pathway, even for APIs with challenging properties, such as low aqueous solubility and poor bioavailability.
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Engineering Approaches To Respiratory Drug Delivery: Mannitol Case Study
5/27/2022
This article presents a case study that explores the material and performance properties of spray-dried and jet-milled mannitol for respiratory delivery of crystalline mannitol.
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Complete Structural Elucidation Of Lipids In A Single Experiment Using Electron Activated Dissociation (EAD)
5/24/2022
Here, electron activated dissociation (EAD) on the ZenoTOF 7600 system is used for the complete structural elucidation of glycerophospholipids, sphingolipids, and acylglycerols in a single experiment.
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Orthogonal Fragmentation Mechanism Enables New Levels Of Metabolite Characterization
5/10/2022
Fragmentation is required to provide structural information about metabolites during drug discovery. Here, two orthogonal fragmentation techniques are compared to determine the in vitro metabolism of the drug darunavir.
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Preserve Particularly Labile Post-Translational Modifications
5/10/2022
This application note studies the site-localization of malonylated peptides using the SCIEX ZenoTOF 7600 system.
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High-Throughput Characterization Of RNA
5/9/2022
How a multi-capillary electrophoresis (CE) system is used to efficiently separate a wide range of RNA-based molecules by size and demonstrates the multiplex capability for RNA characterization.
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Parallel Processing Of Charge Heterogeneity Analysis Of Protein Therapeutics
5/4/2022
In this technical note, we demonstrate parallel, highly reproducible capillary isoelectric focusing analysis using a multi-capillary separation approach to accelerate analysis time.
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Acceleration Of Method Optimization For AAV Capsid Purity Analysis
5/2/2022
We highlight how a multiparameter approach using CE-SDS with laser-induced fluorescence detection (LIF) can significantly expedite methods development and optimization of AAV capsid purity analysis.
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Ensure High Quantity And Quality Of Isolated Bacterial Ribonucleic Acid (RNA)
4/29/2022
In this scientific brief we evaluate the performance of the the Pall Nucleic acid binding (NAB) Nanosep centrifugal device for nucleic acid isolation.