Application Note

Automated Cell Washing And Formulation In CAR T Cell Therapy Manufacturing

Source: Cytiva
GettyImages-2154252378 CAR T Cells - Isometric View 3D Illustration

Continued advancements in treating hematologic malignancies and solid tumors are being achieved with promising methods such as T cell receptor (TCR) and chimeric antigen receptor (CAR) T cell therapies. Given the increasing number of clinical trials in the cell and gene therapy markets each year, greater automation is necessary. A critical first step in evaluating automated technologies for these complex manufacturing workflows is to identify instruments that streamline the production process. The Sefia Select™ system, a functionally closed system, has been developed for automated upstream and downstream cell processing steps using dedicated application software. The S-Wash and ReadySelect applications are designed specifically for the Sefia Select™ system to perform cell washing and formulation and can automate multiple time-sensitive CAR T process steps. Explore data collected from a study utilizing healthy donors in a typical CAR T cell processing workflow, primarily focused on the capabilities and performance of the S-Wash and ReadySelect applications.

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