Drug Discovery App CS WP

  1. Improving Gene Therapy Development With Organ-On-A-Chip Technology 8/7/2024

    Explore the current challenges of developing gene therapies, the potential of Organ-on-a-Chip technology, the future of gene therapy, and more.

  2. From CLD To CDMO: Demonstrating A Successful Cell Line Technology Transfer 8/5/2024

    Explore critical considerations for biopharmaceutical developers and CDMOs during technology transfer as well as a successful transfer and scale-up of a cell line from a CLD platform to a global CDMO.

  3. Harmonizing Regulatory Guidelines For Assay Validation 7/24/2024

    Explore a detailed process for validating ligand-binding assays, particularly for Fcγ receptor binding analytes or other structural isoforms.

  4. TFF Cassettes With 100 kDa Membranes For RNA And LNP Applications 7/3/2024

    This study showcases the performance of regenerated cellulose flat sheet membranes with a 100 kDa molecular weight cutoff for UF/DF of RNA molecules by TFF.

  5. Media And Buffer Mixing Using The Xcellerex™ Magnetic Mixer 6/19/2024

    A common requirement for media and buffer preparation in biopharma processing is powder-liquid mixing. Review the performance of a 3000 L single-use mixing system for preparing aqueous solutions.

  6. Determining The Power Numbers For A Single-Use Mixing System 6/19/2024

    In designing a mixing process for scale-up, the power number is a critical parameter. Explore the determined power numbers for a single-use mixer at various mixing speeds and fill levels.

  7. Automated Cell Washing And Formulation In CAR T Cell Therapy Manufacturing 6/14/2024

    Explore data collected from a study utilizing healthy donors in a typical CAR T cell processing workflow without a transduction step from a cross-site validation study.

  8. Revolutionizing Drug Discovery From "Undruggables" To AI 6/10/2024

    Explore four current trends in drug discovery, how each trend addresses some of the most crucial challenges in drug discovery, and the obstacles to their widespread adoption.

  9. A Hybrid Modeling Approach To Accelerate Media And Feed Development 6/7/2024

    Explore the outcomes of a study focusing on building a mechanistic model to determine the growth kinetics of a CHO-based process producing a mAb.

  10. Considerations For Developing The Recirculation/Perfusion Process 6/6/2024

    Learn about the recirculation and perfusion processes made possible by single-use, fixed-bed bioreactors designed for scaling up adherent cell culture processes.