Drug Discovery App CS WP

  1. Evaluating CAR T-Cell Therapy Vascular Recruitment, Trafficking, And Killing 4/24/2024

    Learn about a more human-relevant platform that enables researchers to assess the trafficking and killing efficiency of immunotherapy as well as the proof-of-concept of immuno-oncology co-therapy.

  2. Optimizing Human iPSC Aggregate And Organoid Production For Bioprinting 4/17/2024

    This study aimed to identify the optimal cell culture conditions to yield high cell density and maintain high cell viability with consistent aggregate morphology and pluripotency marker expression.

  3. Evaluating On-Target/Off-Tumor Effects Of Cancer Immunotherapies 4/9/2024

    A promising class of engineered T-cell engaging bispecific antibodies (TCBs) is revolutionizing cancer treatment, but safety concerns persist. Organs-on-Chips offer a human-relevant solution.

  4. Exploring Neuroinflammation, Neurodegeneration With A Brain Organ-Chip 4/9/2024

    Examine how Organ-on-a-Chip technology, accurately mimicking human neuroinflammation, offers promising human-relevant avenues for neurodegenerative disease research and therapeutic development.

  5. Studying Gut Inflammation And Barrier Disruption With Organ-On-A-Chip Technology 4/9/2024

    See how the Colon Intestine-Chip has been employed to model cytokine-mediated inflammation and barrier disruption in the intestine.

  6. Predicting Human Liver Damage With A More Accurate In Vitro Hepatotoxicity Assay 4/9/2024

    This study explores whether a species-specific, multicellular, in vitro hepatotoxicity assays utilizing Liver-Chips can provide a greater understanding of hepatotoxicity mechanisms than animal models.

  7. Investigating Key Mechanisms Of Parkinson's With A Brain-On-A-Chip 4/9/2024

    Efforts to develop a dynamic “brain-on-a-chip” model that closely resembles the human substantia nigra could be applied to study mechanisms of Parkinson’s disease.

  8. A Better Immune Response To Vaccination: Using Lymphoid Follicle Organ-Chips 4/9/2024

    Discover a first-of-its-kind human LF-Chip containing B, T, plasma and antigen-presenting cells to test functional immunization responses to vaccines and adjuvants in vitro.

  9. Creating An Effective Pre-Clinical Model Of Bone Marrow 4/9/2024

    Uncover how the Bone Marrow-Chip (BM-Chip) can be used as an effective model for studying human bone marrow pathophysiology and explore its range of applications in the field of medicine.

  10. Revolutionizing Viral Infectious Disease Research And Drug Discovery 4/8/2024

    Learn how Organ-Chips are being used to rapidly identify promising treatments, investigate virus evolution, and analyze how mechanical forces influence the innate immune response to viral infections.