Drug Discovery App CS WP
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Duodenum Intestine-Chip For Modeling Human Physiology
3/14/2024
Discover an Intestine-Chip that integrates the robust cell sourcing of organoids with Organs-on-Chips technology to overcome experimental limitations and yield a closer-to-human transcriptomic profile.
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Development And Characterization Of The Species-Specific Liver-Chip
3/14/2024
There is a growing need for more human-relevant preclinical models. Explore how Organ-Chips offer a viable solution and can be used to create a comprehensive recapitulation of the liver sinusoid.
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Characterization Of The Colon Intestine-Chip
3/14/2024
Learn about the development and characterization of Organ-Chips and what makes them the most comprehensive model of the colonic epithelial-endothelial interface that is commercially available.
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Testing The Transduction Of AAV-Based Therapeutics
3/14/2024
Organ-on-a-Chip technology has emerged as a solution to the limitations of conventional preclinical models. Learn how Liver-Chips can be used to test the delivery efficiency and safety of AAV vectors.
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Modeling Inflammation-Specific Immune Cell Recruitment
3/13/2024
Traditional models for studying inflammatory bowel disease (IBD) often fall short. See how the Colon Intestine-Chip was used to model the progression of IBD driven by immune cells more completely.
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Advanced In Vitro Duodenal Model For Toxicity Assessment
3/13/2024
Here, we review how an advanced in vitro model closely aligned with the human duodenum was utilized to evaluate the toxicity of indomethacin, a known gastrointestinal toxicant.
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Cytokine-Mediated Inflammation In A Relevant Preclinical Model
3/13/2024
Learn about a novel preclinical model and how it enables the study of cytokine-mediated barrier inflammation mechanisms as well as the efficacy of anti-inflammatory therapeutics.
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The Application Of The Species-Specific Liver-Chip In Predicting Hepatoxicity
3/13/2024
An evaluation of 150 drug candidates causing adverse events in humans revealed testing in rats and dogs predicted only 71% of toxicities in humans. Discover a solution to this translational challenge.
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Sterilizing Grade Filter Performance With Biologic Drugs
3/11/2024
Examine the throughput performance of sterilizing grade filters across moderate-to-high concentrations of mAbs and immunoglobulins as well as how filter selection can impact your process.
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Exosome Isolation By TFF And Size Exclusion Chromatography
3/6/2024
Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.