Drug Discovery App CS WP

  1. Preserve Particularly Labile Post-Translational Modifications 5/10/2022

    This application note studies the site-localization of malonylated peptides using the SCIEX ZenoTOF 7600 system.

  2. High-Throughput Characterization Of RNA 5/9/2022

    How a multi-capillary electrophoresis (CE) system is used to efficiently separate a wide range of RNA-based molecules by size and demonstrates the multiplex capability for RNA characterization.

  3. Parallel Processing Of Charge Heterogeneity Analysis Of Protein Therapeutics 5/4/2022

    In this technical note, we demonstrate parallel, highly reproducible capillary isoelectric focusing analysis using a multi-capillary separation approach to accelerate analysis time.

  4. Acceleration Of Method Optimization For AAV Capsid Purity Analysis 5/2/2022

    We highlight how a multiparameter approach using CE-SDS with laser-induced fluorescence detection (LIF) can significantly expedite methods development and optimization of AAV capsid purity analysis.

  5. Ensure High Quantity And Quality Of Isolated Bacterial Ribonucleic Acid (RNA) 4/29/2022

    In this scientific brief we evaluate the performance of the the Pall Nucleic acid binding (NAB) Nanosep centrifugal device for nucleic acid isolation.

  6. Flexibility And High-Quality Extraction Of Genomic DNA And RNA From Yeast, Saccharomyces Cerevisiae 4/29/2022

    In this report, we analyze the quality and quantity of gDNA as well as RNA from S. cerevisiae with Pall NAB Nanosep centrifugal devices in comparison with a renowned commercial brand.

  7. How Syringe Filtration With Integrated Prefilter Technology Improves HPLC Performance And Throughput 4/29/2022

    In this article we review how particulate removal through filtration effects column life and how to handle difficult to filter samples.

  8. Nucleases - Are They A Problem For NAB Nanosep® Centrifugal Devices? 4/29/2022

    We examine whether the sample tubes and collection tubes of the NAB Nanosep centrifugal devices contain detectable amounts of DNase or RNase.

  9. How High-Performance Syringe Filters Extend The Life Of Analytic Instruments And Columns 4/28/2022

    This scientific brief reviews how high-performance syringe filters protect and extend the life of analytical HPLC and UHPLC instruments and columns.

  10. DNA Purification From PCR Or Agarose Gels 4/28/2022

    This study assesses the use of NAB Nanosep centrifugal devices with commercially available reagents for PCR or agarose gel cleanup.