Drug Discovery App CS WP
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Optimizing Kinetics Assays To Avoid Avidity Effects
1/31/2024
Considering affinity and avidity early in assay design can ensure the desired assay parameters are achieved. Learn about affinity and avidity and how to recognize and resolve issues that may arise.
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The Key To Accelerating RNA-LNP Drug Development
12/27/2023
Learn about the drug development hurdles that must be overcome to deliver on the promise of mRNA.
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Safer And Faster Conjugation And Purification Of ADCs At 1-20 L Scale
12/5/2023
Explore data demonstrating the successful engineering of a single-use tangential flow filtration system designed to meet the specific requirements of ADC processes.
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Optimizing End-To-End Processes To Reduce Costs And Improve Yields
11/30/2023
Explore the challenges faced by a large CDMO as well as the solutions that were provided to achieve significant time savings, cost savings, and the removal of a major downstream process limitation.
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Reagents For Highly Efficient T Cell Manufacturing
11/29/2023
See how enhanced T cell expansion as well as the generation of an early-differentiated phenotype can be achieved using a cell culture medium for T cells and cytokines, in a static bioreactor system.
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Chromatographic Separation Of Full And Empty AAV8 Capsids
11/29/2023
Here, we demonstrate a rapid method for the separation of empty and full AAV8 particles by linear gradient elution on CIMmultus® QA monoliths with 80% recovery.
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Intensifying A mAb Polishing Platform
11/29/2023
We demonstrate how a mAb purification batch process can be converted into a stepwise intensified batch process, successfully eliminating intermediate steps and achieving over 13% cost reductions.
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Optimizing And Intensifying ADC Aggregate Removal With A DoE Approach
11/29/2023
This study explores the feasibility of using single-use chromatography membrane technology as an alternative to resin-based chromatography in an ADC process.
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Increasing Bioavailability With Amorphous Solid Dosage Formulations
11/10/2023
Discover the challenges associated with pH-dependent solubility for oral tyrosine kinase inhibitor drugs and how leveraging ASD formulation can help create more effective, patient-friendly drug products.
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Extractables And Leachables: Risk Management And Analytical Solutions
10/11/2023
Partnering with a CDMO that offers comprehensive and robust E&L studies can help facilitate a smooth product launch by ensuring minimal impact from impurities, all while mitigating risks.