Application Note

Resolute® BioSMB 80/350 System

Source: Sartorius
Resolute® BioSMB 350 System

The first flow path, multi-column chromatography solution that can be scaled from process development (PD) laboratories to GMP manufacturing is the Sartorius Resolute® BioSMB platform. The Resolute® BioSMB 80/350 system is designed to seamlessly transition an existing PD-scale continuous purification to a process-scale continuous purification, accommodating feedstreams from fed-batch bioreactors up to 2,000 liters. This scalable process maintains consistency without altering the resin, buffer system, or product quality assays when developed on the Resolute® BioSMB PD system. The Resolute® BioSMB platform ensures process consistency at all scales and is practical for flexible, multi-product facilities. Continue reading to explore results from a study scaling up a monoclonal antibody (mAb) capture process utilizing the Resolute® BioSMB platform.

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