Drug Discovery App CS WP

  1. Predicting Human Liver Damage With A More Accurate In Vitro Hepatotoxicity Assay 4/9/2024

    This study explores whether a species-specific, multicellular, in vitro hepatotoxicity assays utilizing Liver-Chips can provide a greater understanding of hepatotoxicity mechanisms than animal models.

  2. Investigating Key Mechanisms Of Parkinson's With A Brain-On-A-Chip 4/9/2024

    Efforts to develop a dynamic “brain-on-a-chip” model that closely resembles the human substantia nigra could be applied to study mechanisms of Parkinson’s disease.

  3. A Better Immune Response To Vaccination: Using Lymphoid Follicle Organ-Chips 4/9/2024

    Discover a first-of-its-kind human LF-Chip containing B, T, plasma and antigen-presenting cells to test functional immunization responses to vaccines and adjuvants in vitro.

  4. Creating An Effective Pre-Clinical Model Of Bone Marrow 4/9/2024

    Uncover how the Bone Marrow-Chip (BM-Chip) can be used as an effective model for studying human bone marrow pathophysiology and explore its range of applications in the field of medicine.

  5. Revolutionizing Viral Infectious Disease Research And Drug Discovery 4/8/2024

    Learn how Organ-Chips are being used to rapidly identify promising treatments, investigate virus evolution, and analyze how mechanical forces influence the innate immune response to viral infections.

  6. Evaluating Cell Culture Medium Performance In CAR-T Processes 4/8/2024

    This study examines the expansion, functionality, and phenotype of CAR-T cells cultured in the CellGenix® GMP T cell culture medium (TCM) compared to other commercially available T cell media.

  7. Real-Life Application Of Intensified Chromatography – See The Results 4/5/2024

    Explore the impact and benefits of multi-column chromatography, taking into consideration product quality consistency as well as the potential cost and resin savings compared to batch chromatography.

  8. Get Full Control Of Your T Cell Isolation 3/25/2024

    This study demonstrates the automated magnetic isolation of CD4/CD8+ cells from fresh or frozen leukapheresis using a functionally closed cell processing system paired with a modular application.

  9. Manufacturing Challenges With High Concentration Biologics 3/18/2024

    Explore key process operations, some of the challenges in manufacturing high-concentration biologics, and factors to consider for process optimization.

  10. Proximal Tubule Kidney-Chip For Modeling Human Physiology 3/14/2024

    Discover how an Organ-Chip can be used to create a comprehensive recapitulation of the proximal tubule, addressing the need for more human-relevant preclinical models in the pharmaceutical industry.