Drug Discovery Featured Articles & Applications

  1. Top 5 Events That Can Impact Your Clinical Supply Chain

    A review of several “small changes” that are pieces of the supply chain puzzle and can wreak havoc if not planned for in advance.

  2. Collegium Pharmaceutical’s Approach To Abuse Deterrence Breaks New Ground

    To address the ongoing public health crisis related to opioid abuse, Xtampza® ER, an oral ER abuse-deterrent formulation of oxycodone, has been developed to resist the ability of abusers to tamper with the product and alter the route of administration.

  3. Can Your Clinical Supply Chain Pass The Brexit Pressure Test?

    - Clinical trial sponsors and clinical supply vendors must fully consider all attributes of their supply chains to ensure continuity of supply post-Brexit. This whitepaper outlines many questions that sponsors and vendors alike should ask

  4. Are Today’s Processes Efficient Enough For The Future Of Vaccine And Viral Vector Production?

    By recognizing the limitations of today’s production processes, the industry may be able to overcome the challenges, complexity, and high cost of manufacturing vaccines and viral vector-based therapies.

  5. Strategies for Efficient Clinical Supply Management and Forecasting

    Engaging clinical supply management and forecasting adds value by evaluating different response strategies and contingency plans and can identify supply solutions that minimize or even potentially avoid supply chain disruptions.

  6. Recent Developments In ADC Technology: A Harbinger Of Future Clinical Trends

    The ADC field is in a transitional period. Older approaches to conjugate composition and dosing regimens still dominate the ADC clinical pipeline, but preclinical work is driving a rapid evolution in how we strategize to improve efficacy and reduce toxicity towards better therapeutic outcomes. In an indication of future directions for the field, antibody conjugates bearing non-cytotoxic small molecule payloads are being developed to reduce side effects associated with treatment of chronic diseases.

  7. Accelerate Complex Molecule Development by Optimizing Chemical Synthesis and Formulation

    The importance of optimizing the chemical synthesis and formulation processes in complex molecule development.

  8. Improved Bioavailability Of Trio Medicines In 12 Weeks

    Learn how a structured 3-step approach can help overcome the challenge of molecular characterization and a limited budget.

  9. Modular Approaches For Diverse Molecules: Reinventing Smart Bioprocessing

    Smart bioprocessing uses bioinformatics, lab-scale processing, and analytics to create efficient and cost-effective production processes that can be verified at lab-scale before scale-up.

  10. Efficient Purification Of The Pertussis Antigens Toxin, Filamentous Haemagglutinin, And Pertactin In Chromatography Workflows

    Read how this method resulted in higher purity and yield than what can be expected from a purification process based on salt precipitations and sucrose gradient centrifugation.