Drug Discovery Featured Articles & Applications
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Formulation Development Of A JAK1 Inhibitor Extended-Release Tablet
6/19/2025
This scientific article presents a summary of the formulation development strategy of a JAK1 inhibitor extended-release tablet, with a focus on experimental design, data interpretation, and formulation decision-making.
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A Guide To Designing mRNA Medicines
6/10/2025
A poorly designed mRNA sequence can create ongoing difficulties during downstream clinical development and manufacture. Let's take a closer look at strategies and design software that you can employ.
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Bracing For The Impact Of The Federal Workforce Reduction
6/9/2025
The federal workforce reductions pose significant challenges for the life sciences industry, particularly for R&D, supply chain oversight, and industry workforce development.
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Radiopharmaceuticals: Navigating FDA Guidance And CMC Considerations
6/2/2025
The unique nature of radiopharmaceuticals necessitates specialized regulatory considerations, particularly for chemistry, manufacturing, and controls (CMC).
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Designing Our Way Toward Circular RNA Medicines With AI
5/21/2025
The closed-loop structure of circular RNA can offer sustained, durable expression. We caught up with Sail Biomedicines' Kerry Benenato and Rajesh Ramaswamy to chat about ways to leverage AI for design/engineering.
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Will Genome Modifications Define Next-Gen AAV Vectors?
5/20/2025
AAV vectors composed of naturally occurring capsids are suboptimal. Gentle genetic alterations hold promise for safer, more efficient therapy.
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Formulation Is Key For Y-mAbs' Self-Assembling Antibody
5/16/2025
The radiotherapy company's novel SADA construct uses self-assembling tetramers to deliver isotopes directly to cancer cells for a highly targeted, less toxic treatment.
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ADCs Unleashed: Navigating Development Hurdles In Targeted Cancer Therapy
5/12/2025
Despite their potential to revolutionize treatment paradigms, antibody-drug conjugates (ADCs) face challenges that companies must tackle for successful development.
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Protecting Intellectual Property In The Genomics Revolution
5/9/2025
Providing superior IP protection for genomics-related inventions already requires — and will require in the future — a more nuanced strategy combining patents, trade secrets, and copyrights.
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PheWAS Is Your Friend
5/7/2025
Discovery and preclinical development expert Stephen Pinkosky, MD, Ph.D. explores the resurgence and growing impact of PheWAS and multi-omics in drug development.