Drug Discovery Featured Articles & Applications

  1. Perfusion – Do’s And Don’ts To Cut Production Costs, Increase Efficiency

    Setting up a perfusion process is complex, and getting the best out of it requires an awareness of the do’s and don'ts of the approach.  Design of experiment (DoE) and quality by design (QbD) approaches help the development of a production process that is both cost-effective and high quality.

  2. Batch And Fed Batch Culture — Practical Steps For Better Results

    Design of Experiments (DoE) mathematical models can help create the perfect environment for batch and fed batch cultures. Understanding the different criteria  and their interactions with each other can be a key differentiator in the race to get your drug to market. 

  3. Fermentation And Cell Culture: Bringing The Basics To The Fore

    Fermentation and cell culture can be carried out in batch or continuous processes.  Reminding ourselves of the basics is vital for the development of more cost-effective and efficient biotech production processes. This article reviews those basics to understand the methods best suited for your development.

  4. Practical Guidelines For Lab-Scale Processing In Volumes <50L

    The understanding of lab-scale processing, from cell and media type to bioreactor size and scale-up, is a vital part of its development. This article reviews the key steps and considerations to aid in developing the process while keeping costs down.

  5. Early CMC Work Sets Groundwork For Regulatory Success

    Understand how the more support and guidance small biopharmaceutical companies receive in terms of CMC expertise, the better groundwork it will lay for a successful IND filing.

  6. Dealing With Demand Uncertainty In Biologics

    When a biologics company is preparing to launch a new product, its manufacturing capacity forecast is subject to a great deal of uncertainty. Biologics developers must consider scale and volume — in that order.

  7. Streamlined Supply Chain Solutions Boost Efficiency

    When customers consolidate their supply chain and use one vendor from drug substance through drug product, it can transform the entire drug development process into a more efficient system.

  8. What You Need To Know To Avoid Costly Delays In Your API Scale-Up

    If, in the course of the development process, undesirable effects occur that negatively impact API scale-up, it can prevent a company from delivering a product with reliable quality and efficacy. 

  9. Zydis® ODT - Improved Therapeutic Profile

    Zydis® fast dissolve formulation for Zelapar® (Selegiline anti-Parkinson’s compound) had a positive impact on the patient compliance as compared to the Selegiline traditional tablets.

  10. Optimizing Clinical Outcomes For Challenging Molecules With Lipid-Based Drug Delivery Systems

    This article takes an in-depth look at how lipid-based drug delivery systems can be used as a bioavailability enhancing technology, as well as the softgel dosage form for their delivery.