Drug Discovery Featured Articles & Applications

  1. How To Drive Down Laboratory Operating Costs With SaaS
    3/6/2017

    As the capabilities and functions inherent in Softwareas-a-Service (SaaS) solutions have matured and gained market acceptance, many vendors are offering SaaS versions of their software. SaaS solutions replace large upfront fees and costs with periodic payments at a fraction of the price, thus offering cost-effective alternatives to traditional packaged applications. This white paper explores best practices in SaaS selection and incorporation into laboratory practices that enable organizations to focus on their core competencies while utilizing best-of-breed software tools to achieve robust yet low-cost laboratory technology.

  2. Millennium’s ELN Empowers Chemists And Biologists
    3/3/2017

    Conventional wisdom holds that biology is not just more complex to manage electronically, but actually more resistant than other areas of discovery to electronic systems such as electronic laboratory notebooks (ELNs). But Millennium, the Takeda Oncology Company, found that by clearly defining workflows and implementing a highly configurable notebook, it could begin moving its entire discovery organization—encompassing both chemists and biologists—to a single ELN system.

  3. How Broadening The Analysis Of Compound Factors Allows For Predictive Solubility Solutions
    3/2/2017

    The Biopharmaceutics Classification System (BCS), developed by the U.S. Food and Drug Administration to simplify and accelerate the drug development process. The system has evolved to classify low-soluble drugs according to their permeability (BCS Class II or IV). A compound’s classification (I through IV) is indicative of its potential bioavailability.

  4. Automation, Modularity Allow mAb Biotech To Cut Scale-Up Time
    2/14/2017

    Biomanufacturers, especially those facing the debut of biosimilars in core markets, have an urgent imperative to reduce manufacturing costs via increased productivity and yields. In turn, this drives a wide range of business decisions, including capital investment, process choices and design, and equipment selection. Learn how AlphaMab Co. Ltd, a fast-growing bio-developer and producer, cut scale-up time using a Quality by Design (QbD) approach.

  5. How Image Analysis Can Improve The Results Of Drug Development And Clinical Trials
    1/24/2017

    In recent years there have been several potentially life-saving medications approved for cancer treatment, including targeted molecular entities and biologics such as Opdivo (nivolumab) and Keytruda (pembrolizumab). Oncology drugs remain a pharmaceutical priority and investments into cancer account for 30% of all pre-clinical and phase 1 clinical development expenditures. There is an impressive list of close to 800 drugs and vaccines currently in the industry-wide development pipeline, many with promising results in early-stage clinical trials. However by historical measures only 10% or fewer of these drugs will ever make it through FDA approval and become part of routine patient care.

  6. Five Major Benefits of Tissue Phenomics
    1/24/2017

    Seeing is believing – this is an important aspect of Tissue Phenomics, where cellular structures in tissue slides taken from patients are investigated in real space. Observing directly what type of structures form and what kind of interactions take place is in general of much higher value than concluding indirectly from other type of data. I experienced this factor very clearly thirty years ago when people speculated about the atomic structure on the surfaces of matter from indirect measurement.

  7. 3 Ways Tissue Image Analysis Will Shape The Future Of Cancer Treatment With Immunotherapies
    1/24/2017

    As healthcare continues its transition towards precision medicine, physicians are eager to maximize both the quantity and quality of data obtained from their patients’ tissue samples.  In the current “one drug, one test” paradigm, physicians struggle to balance the number of tests required to make a treatment decision with the limited amount of tissue that is available. 

  8. Implementing Next-Generation Laboratory Informatics
    1/19/2017

    Electronic Lab Notebooks are a key component of an electronic lab environment that helps scientists execute faster, more informed, high-quality science. It’s a vision scientists have talked about for decades.

  9. How AstraZeneca Improved Validated Workflows In GMP API Manufacturing
    1/18/2017

    The reality is that paper is more of a habit than a requirement. AstraZeneca discovered this when they aimed to introduce ELNs to improve the efficiency of their validated workflows for GMP API manufacture.

  10. Streamlining Change Control In Today’s Complex Life Sciences Organizations
    1/11/2017

    Change control is collaborative, iterative and labor-intensive. For any specific change event, multiple users are required to follow a prescribed set of tasks and processes, which need to be carried out in a defined sequence and are subject to multiple stages of review and approval. It’s very easy to lose track of where you are in the process, what actions need to be completed next, who owns them, and when they are due. Yet the consequences of such lapses can be very costly. This paper examines why it is absolutely vital for organizations to take a comprehensive, closed-loop approach to automating change management, spanning all areas of the organization and extending throughout the product lifecycle.