Application Note

T-Series TFF Cassettes With Delta 100 kDa Membranes For RNA And LNP Applications

Source: Cytiva

By Divakara Uppu, Mark Auger Jr, Roman Kondra, Adam Hejmowski, and Nicholas Marchand

GettyImages-1409578453-mRNA-LNP-lipid-nanoparticle-RNA therapy

Cytiva has introduced Delta regenerated cellulose (RC) flat sheet membranes with a 100 kDa molecular weight cutoff (MWCO) for ultrafiltration/diafiltration (UF/DF) of RNA drug therapeutics through tangential flow filtration (TFF). In this study, the performance of the Delta 100 kDa membrane cassettes for UF/DF of RNA molecules by TFF is evaluated. Explore data showcasing the effectiveness of this membrane cassette for use in processing mRNA, saRNA, and LNPs.

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