Drug Discovery App CS WP
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Cytokine-Mediated Inflammation In A Relevant Preclinical Model
3/13/2024
Learn about a novel preclinical model and how it enables the study of cytokine-mediated barrier inflammation mechanisms as well as the efficacy of anti-inflammatory therapeutics.
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The Application Of The Species-Specific Liver-Chip In Predicting Hepatoxicity
3/13/2024
An evaluation of 150 drug candidates causing adverse events in humans revealed testing in rats and dogs predicted only 71% of toxicities in humans. Discover a solution to this translational challenge.
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Sterilizing Grade Filter Performance With Biologic Drugs
3/11/2024
Here, we analyze the throughput performance of sterilizing grade filters across moderate-to-high concentrations of mAbs and immunoglobulins, demonstrating how filter selection can impact your process.
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Exosome Isolation By TFF And Size Exclusion Chromatography
3/6/2024
Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.
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A Scalable Single-Use Two-Step pDNA Purification Process
3/6/2024
Evaluate the performance of a single-use two-step plasmid purification process, and see how it compares to the existing three-step purification method.
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Five Essentials For Accurate Oligonucleotide Chemistry
3/4/2024
Explore five key areas in oligonucleotide chemistry where improvements will have a huge influence on your synthesis quality.
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Using Automated Spinoculation For CAR T Cell Lentiviral Transduction
2/26/2024
There is a growing demand for closed and automated lentiviral transduction steps in CAR T cell therapy workflows. Learn about a potential solution to address this unmet need.
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A New Way To Perform mAb Capture
2/21/2024
Combining high-productivity chromatography methods and SU affinity membranes delivers a viable alternative to the current packed bed Protein A capture techniques for intensified purification of mAbs.
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Re-Imagining Chromatography: Building Efficient Downstream Processes
2/21/2024
Explore a stepwise approach for integrating process intensification principles into an existing process to increase productivity, reduce costs, and improve process sustainability.
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Integrated And Connected Downstream Processing Of mAbs
2/21/2024
We describe how intensifying two chromatography polishing steps by developing unit operations using Sartobind® Q and CMM HyperCel saves buffer volumes and accelerates the downstream process.