Drug Discovery App CS WP

  1. High-Throughput Multi-Capillary SDS Gel Electrophoresis Of Proteins 7/1/2022

    Discover how a multi-capillary system can be used to accelerate development of sensitive, high-throughput analytical methods, while potentially decreasing time to market for biologics.

  2. Differentiation Of Leucine And Isoleucine Using Electron Activated Dissociation (EAD) 6/23/2022

    We demonstrate the combination of routine characterization and elucidation of challenging residues in one single analysis, without the need for sample specific optimization.

  3. Comprehensive Peptide Mapping Of Biopharmaceuticals Utilizing Electron Activated Dissociation (EAD) 6/21/2022

    We demonstrate in-depth peptide mapping of new and complex molecules, as well as standard monoclonal antibodies (mAb), that can be achieved with this system in a fully automated fashion.

  4. Precision Powder-In-Capsule Micro-Dosing Accelerates Drug Product Development 6/1/2022

    Precision powder microdosing makes it possible to quickly get formulations to the clinic, saving time, money, and use of limited APIs.

  5. Integrated First-In-Human Services To Streamline End-To-End Development And Manufacturing 6/1/2022

    Lonza’s SimpliFiH®️ Solutions offering is designed to simplify and accelerate the development pathway, even for APIs with challenging properties, such as low aqueous solubility and poor bioavailability.

  6. Engineering Approaches To Respiratory Drug Delivery: Mannitol Case Study 5/27/2022

    This article presents a case study that explores the material and performance properties of spray-dried and jet-milled mannitol for respiratory delivery of crystalline mannitol.

  7. Complete Structural Elucidation Of Lipids In A Single Experiment Using Electron Activated Dissociation (EAD) 5/24/2022

    Here, electron activated dissociation (EAD) on the ZenoTOF 7600 system is used for the complete structural elucidation of glycerophospholipids, sphingolipids, and acylglycerols in a single experiment.

  8. Orthogonal Fragmentation Mechanism Enables New Levels Of Metabolite Characterization 5/10/2022

    Fragmentation is required to provide structural information about metabolites during drug discovery. Here, two orthogonal fragmentation techniques are compared to determine the in vitro metabolism of the drug darunavir.

  9. Preserve Particularly Labile Post-Translational Modifications 5/10/2022

    This application note studies the site-localization of malonylated peptides using the SCIEX ZenoTOF 7600 system.

  10. High-Throughput Characterization Of RNA 5/9/2022

    How a multi-capillary electrophoresis (CE) system is used to efficiently separate a wide range of RNA-based molecules by size and demonstrates the multiplex capability for RNA characterization.