Drug Discovery App CS WP
Establishing A Robust Workflow To Identify High-Performing Clones
Cell line development is a complex, labor intensive, and multistep process. Learn about a platform and host cell line that minimize the risk and timeline to develop high-performing clones.
Process Control And Performance Of A Virus Filtration System
Discover a single-use automated filtration system designed to deliver robust process control and integrity assurance during the critical purification step. Explore its design features, processing control, and more.
Maximize Product Recovery In Bulk Filtration And Filling Flow Paths
Explore a fill system designed to automate product draining and recovery within a batch to standardize processes and minimize non-recoverable hold-up within the filtration and distribution flow path sections.
A Versatile Method For Capsule And Depth Filtration
Learn about a solution that can provide a simple, easy, and versatile method for capsule and depth filtration, allowing a quick, efficient move from cell harvest to purification.
Delivering Pre-IND To IND Safety Studies In Just Three Months
A biotech company partnered with an integrated research, development and manufacturing services company to deliver pre-IND to IND safety studies for a treatment therapy for gut-brain diseases.
Capture Of Bispecific Antibodies And Removal Of Product-Related Impurities
Many antibody variants are prone to aggregation or to forming product-related impurities. Explore the application of a resin with novel selectivity to purify challenging entities.
Successful Filter Integrity Testing Using The WIT Method
Explore the collected best methods/practices to give filter end users the best possible chance of performing a successful water intrusion test.
Generating A Robust Host Cell Line For A Cell Line Development Platform
Learn how cell performance within the context of the cell line development workflow was confirmed with the successful isolation of stable, high-producing clones from three model monoclonal antibodies.
Biacore™ SPR Systems For Titer Analysis Of Adeno-Associated Virus
We describe the performance of two assays for titer analysis of adeno-associated virus (AAV), serotype 2 and serotype 5, based on surface plasmon resonance (SPR).
AAV Production In Suspension HEK293 Cells With Single-Use Bioreactors
Explore how we expanded HEK293/HEK293T suspension cells from small cell culture (20 mL) in shake flasks up to a 10 L culture in a benchtop Xcellerex™ XDR-10 single-use bioreactor system.