Preclinical

PRECLINICAL ARTICLES

Early Decisions That Shape Success In CNS Drug Development And Commercialization, Part 2
In part 2, Ginger continues to provide insights for R&D teams on CNS development and commercialization.
Early Decisions That Shape Success In CNS Drug Development And Commercialization, Part 1
In part 1, we caught up with Ginger Johnson, SVP and neuroscience lead at Lumanity, to discuss how companies can connect the science to the realities of CNS drug development earlier
Fragment-Based Drug Discovery 2.0, Part 2: Practical Workflow, Difficult Target Classes, And Emerging Capabilities
Part 2 focuses on the practical workflow, difficult target classes, emerging capabilities, and the criteria for translating these technologies into better discovery decisions.
Fragment-Based Drug Discovery 2.0, Part 1: Faster, Cleaner Weak-Binding Hit Discovery
This article examines the advances in ¹⁹F NMR, ultra-high-field instrumentation, and contrast-engineered screening.
Pharmacogenomics In Oncology: A Pharmacokinetic Perspective
The outcome of a medical treatment is not solely determined by the efficacy of the drug itself. It also depends on the patient’s genetic makeup, biological characteristics of the disease, and individual clinical factors.
Can We Cure Diabetes?
We caught up with Minutia CEO Katy Digovich to discuss engineered iPSC-derived islets intended for transplantation into the forearm, which could make a functional cure for insulin-dependent diabetes broadly accessible.

PRECLINICAL VIDEOS

Residual DNA Testing Across Biotherapeutics

Residual host cell DNA testing can create bottlenecks. Learn how digital PCR supports more consistent quantification, simpler method deployment, and faster in-process and lot release decisions.

Audience Poll: Validation and Trust Are Biggests Barriers to Organ on Chip Adoption

Validation And Trust Are The Biggest Barriers To Organ On Chip Adoption

In a live audience poll, 46% of respondents cited validation and trust as the biggest barriers to broader organ‑on‑chip adoption. The result suggests the technology itself is no longer the main hurdle; instead, confidence in reproducibility, benchmarking, and fit‑for‑purpose use will determine how quickly these models are integrated into drug discovery decision‑making.

Why Women's Health Is A Breakthrough Use Case For Organ Chips

Women’s health research highlights both the limitations of traditional models and the strengths of organ‑on‑chip systems. Panelists describe how hormone dynamics, immune signaling, microbiomes, and sex‑specific biology can be studied with unprecedented precision, enabling mechanistic insights that were previously inaccessible and opening new paths beyond symptom‑based treatment.

Where Organ On Chips Will Add The Most Value In 3–5 Years

Panelists emphasized that CROs and CDMOs will be essential to scaling organ on chip adoption, but only if they commit to standardized, commercial execution rather than treating these systems as experimental add ons. As Don Ingber put it plainly, CROs “need to start buying these commercial systems and start scaling” them to make organ on chip studies operationally viable for industry.

PRECLINICAL ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

Accelerating Cell Therapy Discovery With High-Throughput Electroporation

Discover how high-throughput electroporation-based screening can compress your CAR-T optimization timeline while delivering reproducible, scale-ready results across multiple donor samples.
Ushering In A New Era Of Human-Relevant Drug Discovery

With most drug candidates failing before approval, researchers need better ways to predict human responses. Gain insight into how advances in human-relevant modeling are helping improve decisions.
How Organ-Chips Are Transforming Women's Reproductive Health Research

Traditional models often fall short in women’s health research. Learn how human-relevant Organ-Chip systems are providing new ways to study vaginal, cervical, and uterine biology.
Organ-On-A-Chip Technology Unlocks Patient-Derived Precision Medicine

Personalized medicine struggles with models that fail to reflect real human biology. Organ-on-a-Chip systems recreate tissue complexity, helping predict patient-specific treatment responses.
How Isogenic Organ-Chips Are Transforming The Future Of Research

Modeling the human brain requires more than simplified systems. New approaches that incorporate diverse cell types are improving how researchers study neurovascular function with greater precision.
The AVATAR Program: Modeling Human Bone Marrow Beyond Earth's Orbit

As deep space missions return, new research is uncovering how human biology adapts beyond Earth. Advanced tissue models offer fresh insight into bone marrow response, opening new possibilities.
Building A Human-Centric Future For Biologics Development

Biologics are advancing rapidly, but complexity challenges traditional models. Gain insight into how human-relevant approaches like NAMs and microphysiological systems are gaining traction.
A Timeline Of U.S. Actions To Reduce Animal Models In Research

Policy and scientific validation have aligned to shift drug development beyond animal models. New regulations and technologies are making human‑relevant methods the standard for preclinical research.
New Approach Methodologies: The Future Of Toxicology And Safety Testing

NAMs are transforming toxicology with human-relevant, non-animal approaches. Learn what defines a NAM, how these methods work together, and why adoption is rapidly accelerating.
LNP-Mediated Cell Transfection In Bioreactors Across Workflows

Lipid nanoparticles are redefining immune cell engineering. Delve into new data that demonstrates the performance across multiple cell types and bioreactor systems, supporting their potential workflows.
Towards A Universal LNP Platform For Multiplex Engineering

Multiplex engineering of T cells for solid tumors requires precise delivery. Emerging LNP approaches enable co-delivery of RNA and DNA, offering a safer, more scalable path beyond viral vectors.
Extrahepatic Delivery Of mRNA-LNP To Spleen

In vivo CAR-T approaches aim to reprogram T cells directly in the body using targeted lipid nanoparticles. Improved delivery to immune organs highlights new potential for scalable cell therapies.

PRECLINICAL SOLUTIONS

Streamline High Throughput Experimentation And Process Development

Software for Automated, Digitalized Experimentation

Katalyst D2D® (Design-to-Decide) provides integrated experiment design, planning, execution, and analysis for high-throughput synthesis, process optimization, and preformulation studies. It helps scientists execute experiments more efficiently and connect data with decisions across the design-make-test-analyze (DMTA) cycle.
Clean Blood And Tissue DNA Kit

Magnetic bead-based genomic DNA extraction kit.
Pipetting Robot For Full Workflow Automation

Frees you from routine pipetting and provides excellent results
Streamlining Magnetic Bead Purifications

We have introduced the MAG and HEATMAG modules with you, the scientists, in mind.
Magnetic Beads For NGS Size Selection And PCR Purification

MAGFLO magnetic beads are only available in Austria, Belgium, Denmark, France, Germany, Ireland, Netherlands, Sweden, Switzerland and the United Kingdom.
Small Molecule Exponential Discovery

Explore how a data‑driven discovery model combines DEL screening, computational insights, and medicinal chemistry to accelerate hit‑to‑lead decisions, reduce risk, and enable efficient progression.
Turning Screening Data Into Discovery Direction

Chemomics transforms full DEL datasets into predictive insights. See how combining large-scale screening with clear computational models accelerates SAR understanding and strengthens confidence.
An Organ-Chip Platform That Generates Human-Relevant Data At Scale

Generate human-relevant data with an Organ-Chip system that combines automation, imaging, and cost efficiency for faster, more confident insights for drug development and complex biological studies.
A Revolutionary Consumable Empowering High-Throughput Organ-Chip Studies

With 12 independent Emulations in one consumable, Chip-Array optimizes workflows and reduces cell requirements—delivering scalable, physiologically relevant models for advanced research.
Complete Organ-Chip Solutions To Fast-Track Your Drug Discovery

From cancer models to high-throughput screening, Organ-Chip platforms accelerate development, improve safety, and support regulatory compliance for next-generation therapies.
A Human-Relevant Liver Model With Minimal Drug Absorption

This human-relevant liver model featuring a rigid plastic is designed to minimize small-molecule drug absorption. Explore the specifications of this product engineered to model the liver.

PRECLINICAL ARTICLES

PRECLINICAL VIDEOS

PRECLINICAL ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

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PRECLINICAL SOLUTIONS