Preclinical

PRECLINICAL ARTICLES

There's A Gap In Brain Tumor Research — Here's How We Fix It
Brain tumors are some of the most biologically complex and least improved indications. Biochemistry researcher and scientist Catherine Bladen, Ph.D., argues sustained focus is a key to driving real-world progress.
AI Drug Discovery Is Revealing The Preclinical Bottleneck
For the generative AI revolution in drug discovery to deliver on its promise, the industry needs more than better molecules, it needs a better pipeline architecture.
Beyond Biologics: A Biophysical Approach To Crohn's Disease
Research into a nano-amorphous approach suggests a new breakthrough in Crohn’s management may come from a shift toward modulating the biophysical environment of the gut.
Does TSLP Inhibition Signal The Next Wave Of Respiratory Biologics?
Thymic stromal lymphopoietin (TSLP) inhibition has firmly established itself as a strategy in respiratory disease. This article highlights some promising drug candidates and next-generation approaches.
What's Next For ADCs: How Combinations Will Help Define The Future Of Treatment
Insights gained from advancing ADC combination therapies in lung cancer are now shaping innovative approaches across multiple tumor types.
From "Live Drug" To Precision Tool: Redefining CAR T Safety
Through important chemistry and the right engineering, there’s new opportunity for CAR T therapeutics to target different forms of cancer with limited toxicity.

PRECLINICAL VIDEOS

Why Requalify?

Qualification is not a one-and-done activity in regulated environments. Learn when requalification is required and how lifecycle-based testing helps ensure equipment performance and compliance.

OptiRun Connect: Faster Support To Minimize Downtime

Real-time monitoring and rapid support help detect issues early and keep critical equipment performing reliably. See how proactive alerts enable faster resolution and more efficient operations.

My Equipment: Online Portal For Repair Requests And Service History

Manage equipment and service information in one place, submit requests from any device, review service history at a glance, and see real-time coverage details to support faster decisions.

Equipment Life Cycle: It's A Commitment

Progress depends on systems that grow with your work. Discover how end‑to‑end support keeps instruments running reliably, reduces long‑term risk, and ensures performance stays aligned with operations.

PRECLINICAL ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

Beyond Hits: The Next Era Of Data-Driven Drug Discovery

Drug discovery is moving beyond traditional hit identification toward data-driven strategies that extract deeper insight from large-scale screening datasets. Advances in DNA-encoded library (DEL) screening, computational tools, and machine learning are helping teams make more informed decisions in early-stage drug development. Access this brand-new Drug Discovery Online content collection for an under-the-hood look at modern approaches to turning large discovery datasets into actionable insight.
One-Step SAR: Using High-Content Imaging To Drive Small Molecule Protein Degraders From Hit To Lead

Discover Curia’s cost-effective high-content immunofluorescence workflow using the Revvity Opera Phenix™ system to efficiently identify small molecule protein degraders with rich, multi-dimensional data.
Translating Massive Data Into Therapeutic Momentum

New advances in chemomics, proteome mapping, and modern synthetic methods are redefining how quickly and precisely discovery teams can move from raw data to meaningful clinical momentum.
How To Become A PCR Pro

Explore how PCR works, what impacts reaction success, and how to troubleshoot common challenges with expert guidance and real lab examples designed to help you strengthen your PCR skills.
Automated DNA Size Selection For Flexible NGS Workflow Integration

Gain insight into automating DNA size selection that shows how optimized bead ratios and programmable handling improve fragment recovery, consistency, and throughput.
Automated Library Prep For Nanopore Human Whole Genome Sequencing

Gain insight into an automated high‑input workflow that streamlines long‑read whole‑genome library prep, supporting large DNA fragments while reducing reagent use.
Automated Library Prep For A Nanopore DNA Barcoding Protocol

A streamlined workflow reduces reagent use and hands‑on time while preserving long‑read sequencing quality. See how multiplexed offer an efficient option for scaling or mobilizing sequencing efforts.
Covalent Warhead Reactivity: A New Look At GSH Reactivity Assays

Understanding covalent warhead kinetics is key to reducing safety risks early in discovery. Learn about a new approach to GSH‑based measurements that offers clearer predictors of toxicity.
Flow Chemistry For Contemporary Isotope Labeling

Gain insight into how late‑stage exchange and flow‑based methods enable efficient access to labeled molecules for pharmaceuticals, mechanistic studies, and analytical applications.
Mirror, Mirror Makes RNA-targeted Discovery Smarter

Examine a mirror‑image screening approach that eliminates DNA:RNA hybridization, revealing true binders and unlocking clearer, more productive DEL results for challenging RNA targets.
The Ultimate Guide To Stress-Free Pipetting

Improve accuracy and reduce stress with expert pipetting tips. Discover how technique and tool selection can boost precision and efficiency, ensuring consistent results across every lab workflow.
Lentiviral Vector Upstream Process

Scalable lentiviral vector production is moving beyond adherent systems. Learn how streamlined workflows enable linear scale-up in stirred-tank bioreactors for cost-effective gene therapy manufacturing.

PRECLINICAL SOLUTIONS

Clean Blood And Tissue DNA Kit

Magnetic bead-based genomic DNA extraction kit.
Pipetting Robot For Full Workflow Automation

Frees you from routine pipetting and provides excellent results
Streamlining Magnetic Bead Purifications

We have introduced the MAG and HEATMAG modules with you, the scientists, in mind.
Magnetic Beads For NGS Size Selection And PCR Purification

MAGFLO magnetic beads are only available in Austria, Belgium, Denmark, France, Germany, Ireland, Netherlands, Sweden, Switzerland and the United Kingdom.
Small Molecule Exponential Discovery

Explore how a data‑driven discovery model combines DEL screening, computational insights, and medicinal chemistry to accelerate hit‑to‑lead decisions, reduce risk, and enable efficient progression.
Turning Screening Data Into Discovery Direction

Chemomics transforms full DEL datasets into predictive insights. See how combining large-scale screening with clear computational models accelerates SAR understanding and strengthens confidence.
An Organ-Chip Platform That Generates Human-Relevant Data At Scale

Generate human-relevant data with an Organ-Chip system that combines automation, imaging, and cost efficiency for faster, more confident insights for drug development and complex biological studies.
A Revolutionary Consumable Empowering High-Throughput Organ-Chip Studies

With 12 independent Emulations in one consumable, Chip-Array optimizes workflows and reduces cell requirements—delivering scalable, physiologically relevant models for advanced research.
Complete Organ-Chip Solutions To Fast-Track Your Drug Discovery

From cancer models to high-throughput screening, Organ-Chip platforms accelerate development, improve safety, and support regulatory compliance for next-generation therapies.
Altasciences' State-Of-The-Art Research Facilities

With over 585,000-sq.-ft. of purpose-built space, our preclinical facilities across North America are designed to support your drug development journey, from early discovery to IND/NDA submission.
Lead Optimization In Drug Discovery

Altasciences specializes in lead optimization studies, helping you identify the most promising drug candidates through precise, data-driven preclinical screening. Our expert scientists tailor each study to your unique needs, utilizing efficient non-GLP screening protocols to accelerate decision-making. With streamlined study designs, clear data visualization, and rapid turnaround times, we provide actionable insights to advance your drug discovery pipeline.
Complex Synthetic Molecule Development, Manufacturing

See how our innovative capabilities and advanced technologies can optimize the development and manufacturing of complex synthetics for drug substances, medical devices, and diagnostic agents.
A Human-Relevant Liver Model With Minimal Drug Absorption

This human-relevant liver model featuring a rigid plastic is designed to minimize small-molecule drug absorption. Explore the specifications of this product engineered to model the liver.
Your Top Partner For Ophthalmic Drug Development

As a leading partner in ocular therapy, Altasciences is at the forefront of ophthalmic drug development. Our integrated CRO/CDMO solutions can support your program from lead candidate selection to market. You will benefit from working with a single partner as your product advances through each phase of drug development—from prototype formulation through preclinical testing, to early phase clinical trials, and manufacturing. This could mean up to 40% in time savings.

PRECLINICAL ARTICLES

PRECLINICAL VIDEOS

PRECLINICAL ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

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PRECLINICAL SOLUTIONS