PRECLINICAL ARTICLES
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From "Live Drug" To Precision Tool: Redefining CAR T Safety
Through important chemistry and the right engineering, there’s new opportunity for CAR T therapeutics to target different forms of cancer with limited toxicity.
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Annual Reflections And Predictions From The Editors' Roundtable
Understanding the full scope of the life science industry has never been more critical. Ray Dogum, Chief Editor of Drug Discovery Online, joins the Life Science Connect Editors’ Roundtable on a special episode of Better Biopharma podcast.
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The Unlikely Weapon Against Fentanyl: Your Immune System
ARMR Sciences Inc. has developed a vaccine designed with a novel adjuvant, dmLT, to neutralize fentanyl in the bloodstream before it reaches the central nervous system and binds to μ-opioid receptors (MORs).
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2025's Top 5 Drug Discovery Highlights And How To Stay Ahead In 2026
Drug Discovery Online's 2025 Top 5 most consequential shifts affecting this rapidly evolving field, including NAMs, AI, Individualized Therapies, Innovating China, and Early-stage Funding Volatility.
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GO‑4 Drug Combo Offers New Hope for Treating Late-Stage BRCA/PALB2-Mutated Cancers
General Oncology’s GO‑4 is an investigational product combining melphalan, BCNU, hydroxocobalamin, and ascorbic acid. The company's CEO, Jeff Glazier shared how the combo is designed to shut down DNA repair and resensitize hard‑to‑treat tumors to chemotherapy for patients with advanced pancreatic or breast cancer.
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Live Insights: 45% Believe The NAMs Industry Should Expand Pre-Competitive Data Sharing Programs
According to a recent poll, 45% of participants believe the NAMs industry should expand pre-competitive consortia by sharing validation data and best practices to reduce duplication and accelerate acceptance. Experts Zahar Nahle, Ph.D. and Samantha Atkins, Ph.D. share their insights.
PRECLINICAL ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS
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Discover Curia’s cost-effective high-content immunofluorescence workflow using the Revvity Opera Phenix™ system to efficiently identify small molecule protein degraders with rich, multi-dimensional data.
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New advances in chemomics, proteome mapping, and modern synthetic methods are redefining how quickly and precisely discovery teams can move from raw data to meaningful clinical momentum.
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Explore how PCR works, what impacts reaction success, and how to troubleshoot common challenges with expert guidance and real lab examples designed to help you strengthen your PCR skills.
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Gain insight into automating DNA size selection that shows how optimized bead ratios and programmable handling improve fragment recovery, consistency, and throughput.
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Gain insight into an automated high‑input workflow that streamlines long‑read whole‑genome library prep, supporting large DNA fragments while reducing reagent use.
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A streamlined workflow reduces reagent use and hands‑on time while preserving long‑read sequencing quality. See how multiplexed offer an efficient option for scaling or mobilizing sequencing efforts.
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Understanding covalent warhead kinetics is key to reducing safety risks early in discovery. Learn about a new approach to GSH‑based measurements that offers clearer predictors of toxicity.
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Gain insight into how late‑stage exchange and flow‑based methods enable efficient access to labeled molecules for pharmaceuticals, mechanistic studies, and analytical applications.
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Examine a mirror‑image screening approach that eliminates DNA:RNA hybridization, revealing true binders and unlocking clearer, more productive DEL results for challenging RNA targets.
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Improve accuracy and reduce stress with expert pipetting tips. Discover how technique and tool selection can boost precision and efficiency, ensuring consistent results across every lab workflow.
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Scalable lentiviral vector production is moving beyond adherent systems. Learn how streamlined workflows enable linear scale-up in stirred-tank bioreactors for cost-effective gene therapy manufacturing.
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A scalable bioreactor process enables efficient expansion of cord blood-derived HSCs and NK cell differentiation, delivering high purity and strong cytotoxicity, advancing immune cell therapies.
PRECLINICAL SOLUTIONS
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Magnetic bead-based genomic DNA extraction kit.
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Frees you from routine pipetting and provides excellent results
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We have introduced the MAG and HEATMAG modules with you, the scientists, in mind.
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MAGFLO magnetic beads are only available in Austria, Belgium, Denmark, France, Germany, Ireland, Netherlands, Sweden, Switzerland and the United Kingdom.
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Explore how a data‑driven discovery model combines DEL screening, computational insights, and medicinal chemistry to accelerate hit‑to‑lead decisions, reduce risk, and enable efficient progression.
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Chemomics transforms full DEL datasets into predictive insights. See how combining large-scale screening with clear computational models accelerates SAR understanding and strengthens confidence.
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Generate human-relevant data with an Organ-Chip system that combines automation, imaging, and cost efficiency for faster, more confident insights for drug development and complex biological studies.
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With 12 independent Emulations in one consumable, Chip-Array optimizes workflows and reduces cell requirements—delivering scalable, physiologically relevant models for advanced research.
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From cancer models to high-throughput screening, Organ-Chip platforms accelerate development, improve safety, and support regulatory compliance for next-generation therapies.
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With over 585,000-sq.-ft. of purpose-built space, our preclinical facilities across North America are designed to support your drug development journey, from early discovery to IND/NDA submission.
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Altasciences specializes in lead optimization studies, helping you identify the most promising drug candidates through precise, data-driven preclinical screening. Our expert scientists tailor each study to your unique needs, utilizing efficient non-GLP screening protocols to accelerate decision-making. With streamlined study designs, clear data visualization, and rapid turnaround times, we provide actionable insights to advance your drug discovery pipeline.
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See how our innovative capabilities and advanced technologies can optimize the development and manufacturing of complex synthetics for drug substances, medical devices, and diagnostic agents.
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This human-relevant liver model featuring a rigid plastic is designed to minimize small-molecule drug absorption. Explore the specifications of this product engineered to model the liver.
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As a leading partner in ocular therapy, Altasciences is at the forefront of ophthalmic drug development. Our integrated CRO/CDMO solutions can support your program from lead candidate selection to market. You will benefit from working with a single partner as your product advances through each phase of drug development—from prototype formulation through preclinical testing, to early phase clinical trials, and manufacturing. This could mean up to 40% in time savings.