Drug Discovery App CS WP
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Process Development Considerations For RNA-LNP Therapeutics
9/13/2022
Here, we highlight three important process considerations across the RNA-LNP manufacturing workflow which includes limit size behavior, in-line dilution and downstream tangential flow filtration (TFF).
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Key Stages In mRNA-Based Therapeutic Development
9/13/2022
Learn how planning a product development strategy early on with a technology partner who has deep expertise and technical knowledge of genomic medicines can address uncertainties from the outset.
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Expansion Of Porcine SK-RST Cells On Microcarriers Via Serial Passage In Stirred Vessels
9/7/2022
By performing a small-scale study with multiple microcarrier types and medias we identify the best microcarrier and media for the expansion of porcine SK-RST cells via microcarrier-based serial passage in stirred vessels.
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SPR Assays To The Assess Similarity Between Innovator And Biosimilar Versions of Nivolumab (Opdivo®)
9/2/2022
Learn more about developed and qualified SPR assays to characterize the binding and affinity of biosimilar and innovator nivolumab for all seven Fc gamma receptors, FcRn and PD-1.
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Expansion Of MRC-5 Cells On Microcarriers Via Serial Passage In Stirred Vessels
9/1/2022
In this application note we characterize MRC-5 cell growth on multiple microcarriers in stirred vessels and present data demonstrating feasibility of serial passage and scale-up into bioreactor expansion of MRC-5 cells.
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Microcarrier Delivery System For Reduced Bioreactor Set Up Time
9/1/2022
This paper evaluates a gamma irradiated, ready-to-use microcarrier delivery system that reduced bioreactor set up time by approximately by 20%.
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Expansion Of MDCK Cells On Microcarriers Via Growth In Stirred Vessels
8/31/2022
We demonstrate how microcarriers provide an ideal substrate for expansion of MDCK cells in closed stirred-vessel systems and lay the groundwork for subsequent developmental studies in larger bioreactor formats.
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Fast, Flexible, And Intelligent Solutions For Buffer Preparation
8/30/2022
We explore a unique single-use technology platform fitting all mixing applications from buffer and media preparations, downstream processes to final formulation in 50 L, 100 L, 200 L, 400 L, 650 L and 1,000 L volumes.
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Abeona Therapeutics Demonstrates Effective Scalability Of Suspension Cells For The Production Of rAAV Viral Vectors
8/30/2022
Learn how this gene therapy company leveraged a scalable production platform to make process development and subsequent scale-up more streamlined offering time and cost savings.
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Move Your Gene Therapy From Strategy To Reality
8/30/2022
Explore how optimizing your process with an end-to-end integrated solution can reduce costs, increase speed to market and get your final gene therapy product within reach of patients.