Drug Discovery App CS WP
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Reagents For Highly Efficient T Cell Manufacturing
11/29/2023
See how enhanced T cell expansion as well as the generation of an early-differentiated phenotype can be achieved using a cell culture medium for T cells and cytokines, in a static bioreactor system.
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Chromatographic Separation Of Full And Empty AAV8 Capsids
11/29/2023
Here, we demonstrate a rapid method for the separation of empty and full AAV8 particles by linear gradient elution on CIMmultus® QA monoliths with 80% recovery.
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Intensifying A mAb Polishing Platform
11/29/2023
We demonstrate how a mAb purification batch process can be converted into a stepwise intensified batch process, successfully eliminating intermediate steps and achieving over 13% cost reductions.
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Optimizing And Intensifying ADC Aggregate Removal With A DoE Approach
11/29/2023
This study explores the feasibility of using single-use chromatography membrane technology as an alternative to resin-based chromatography in an ADC process.
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Increasing Bioavailability With Amorphous Solid Dosage Formulations
11/10/2023
Discover the challenges associated with pH-dependent solubility for oral tyrosine kinase inhibitor drugs and how leveraging ASD formulation can help create more effective, patient-friendly drug products.
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Extractables And Leachables: Risk Management And Analytical Solutions
10/11/2023
Partnering with a CDMO that offers comprehensive and robust E&L studies can help facilitate a smooth product launch by ensuring minimal impact from impurities, all while mitigating risks.
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Simplifying Large-Scale Single-Use Filtration With A Novel Modular Approach
10/2/2023
To meet large-scale production challenges, a modular platform-based approach was developed to offer a simplified, standardized design for protein- and virus-based therapy production processes.
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A Novel Fermenter For High Cell Density Microbial Cultures
9/29/2023
Review the capabilities and robustness of a new single-use fermenter in a fast, exponentially growing, high cell density Escherichia coli (E. coli) process.
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Developing A HIC Polishing Step For The Removal Of mAb Aggregates
9/28/2023
Learn in-depth about the development of a flow-through polishing step that employs hydrophobic interaction chromatography for the elimination of monoclonal antibody aggregates.
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Predictive Modeling Of Viscosity Behavior Using Artificial Neural Networks
9/11/2023
Discover a modeling approach employing artificial neural networks using experimental factors combined with simulation-derived parameters plus viscosity data from 27 highly concentrated mAbs.