Drug Discovery App CS WP

  1. Expansion Of MRC-5 Cells On Microcarriers Via Serial Passage In Stirred Vessels 9/1/2022

    In this application note we characterize MRC-5 cell growth on multiple microcarriers in stirred vessels and present data demonstrating feasibility of serial passage and scale-up into bioreactor expansion of MRC-5 cells.

  2. Microcarrier Delivery System For Reduced Bioreactor Set Up Time 9/1/2022

    This paper evaluates a gamma irradiated, ready-to-use microcarrier delivery system that reduced bioreactor set up time by approximately by 20%.

  3. Expansion Of MDCK Cells On Microcarriers Via Growth In Stirred Vessels 8/31/2022

    We demonstrate how microcarriers provide an ideal substrate for expansion of MDCK cells in closed stirred-vessel systems and lay the groundwork for subsequent developmental studies in larger bioreactor formats.

  4. Fast, Flexible, And Intelligent Solutions For Buffer Preparation 8/30/2022

    We explore a unique single-use technology platform fitting all mixing applications from buffer and media preparations, downstream processes to final formulation in 50 L, 100 L, 200 L, 400 L, 650 L and 1,000 L volumes.

  5. Abeona Therapeutics Demonstrates Effective Scalability Of Suspension Cells For The Production Of rAAV Viral Vectors 8/30/2022

    Learn how this gene therapy company leveraged a scalable production platform to  make process development and subsequent scale-up more streamlined offering time and cost savings.

  6. Move Your Gene Therapy From Strategy To Reality 8/30/2022

    Explore how optimizing your process with an end-to-end integrated solution can reduce costs, increase speed to market and get your final gene therapy product within reach of patients.

  7. Bench To Bedside: A Scalable End-To-End Solution For AAV Production 8/30/2022

    How to efficiently translate bench-scale processes to commercial GMP manufacturing to produce viral vectors at the scale needed to meet dosage requirements.

  8. Evaluation Of Influenza Production In MDCK CD Medium 8/29/2022

    Learn more about the production benefits imposed using MDCK cells that have the potential to significantly reduce lead times for vaccine production and alleviate constraints on raw material supply.

  9. Approaches To Establishing A Perfusion Mimic Process 8/26/2022

    We demonstrate how high throughput perfusion mimic processes can be achieved in microbioreactors with good consistency amongst the replicates and with sustained cell viability and protein production.

  10. Enabling Early Assessment Of Drug Targets To Maximize Success 8/23/2022

    Comprehensive diligence around a target before starting a discovery program can make the difference between success and failure.