Featured Articles

31. Testing The Transduction Of AAV-Based Therapeutics 3/14/2024

    Organ-on-a-Chip technology has emerged as a solution to the limitations of conventional preclinical models. Learn how Liver-Chips can be used to test the delivery efficiency and safety of AAV vectors.

32. Modeling Inflammation-Specific Immune Cell Recruitment 3/13/2024

    Traditional models for studying inflammatory bowel disease (IBD) often fall short. See how the Colon Intestine-Chip was used to model the progression of IBD driven by immune cells more completely.

33. Advanced In Vitro Duodenal Model For Toxicity Assessment 3/13/2024

    Here, we review how an advanced in vitro model closely aligned with the human duodenum was utilized to evaluate the toxicity of indomethacin, a known gastrointestinal toxicant.

34. Cytokine-Mediated Inflammation In A Relevant Preclinical Model 3/13/2024

    Learn about a novel preclinical model and how it enables the study of cytokine-mediated barrier inflammation mechanisms as well as the efficacy of anti-inflammatory therapeutics.

35. The Application Of The Species-Specific Liver-Chip In Predicting Hepatoxicity 3/13/2024

    An evaluation of 150 drug candidates causing adverse events in humans revealed testing in rats and dogs predicted only 71% of toxicities in humans. Discover a solution to this translational challenge.

36. The Importance Of Specificity In Preclinical Drug Development Models 3/13/2024

    It is crucial for models to not only detect toxic drugs but also to avoid erroneously identifying safe drugs as harmful. Learn about the importance of specificity in the early stages of drug development.

37. Unraveling The Complexities Of Cancer Through Human-Relevant Models 3/13/2024

    The current paradigm in preclinical testing for cancer therapeutics is proving inadequate. Learn about Organ-on-a-Chip technology and how it is improving 3D cancer modeling.

38. A More Human-Relevant Model To Advance AAV-Based Gene Therapies 3/8/2024

    Learn about a liver-chip that offers a more human-relevant way of testing viral vectors compared to conventional models and why it is a promising tool for advancing AAV gene therapy.

39. A Century Of Cell Culture And The Rise Of Organ-Chips 3/8/2024

    Despite its advantages in researching biological processes, 2D cell culture suffers from its artificial nature. Learn about 3D cell culture and how it is advancing in vitro studies.

40. Advancing Precision Medicine With Patient-On-A-Chip 3/8/2024

    Emulate and Cedars-Sinai Medical Center have partnered to develop a Patient-on-a-Chip program that combines their stem cell expertise and Organs-on-Chips technology to advance precision medicine.