Modeling A Better Human Immune Response To Vaccination Using Lymphoid Follicle Organ-Chips

Researchers have developed a new model called the LF-Chip that can simulate immune responses similar to those found in secondary lymphoid organs in humans. The LF-Chip contains structures that express molecules indicating immune reactions and can support plasma cell formation and antibody secretion. It was tested with influenza vaccination and showed similar immune responses to vaccinated humans.

This model could be useful for assessing the efficacy and safety of vaccines and adjuvants in a patient-specific manner, as well as studying immune organ formation and antigen-induced immunological responses. This article also discusses the need for more clinically relevant models to study drug-induced thrombosis and mentions different organ-chip models that can be used for this purpose.