Drug Discovery Featured Articles & Applications
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Using AI In Drug Discovery Isn’t The Golden Solution You Think It Is — Yet.
7/17/2023
Before we realize the true potential of advanced artificial intelligence (AI) and machine learning (ML) technologies to treat disease, we need to start by developing technologies that can generate the massive amounts of reliable, high-quality biological data that make up the fundamentals of any AI/ML approach.
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Protein Degraders: Progress, Limitations, & Future Directions
7/12/2023
There is great excitement surrounding the development of small molecules that trigger the degradation of proteins. This article will highlight proteolysis targeting chimeras (PROTACs), their current limitations, and the emerging strategies to address those limitations, resulting in a bright future for targeted protein degradation.
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Better Biomarkers Increase The Probability Of Success In Alzheimer’s Drug Development
7/10/2023
The efficacy of an Alzheimer's disease therapeutic is measured by the change in a patient's cognitive ability and can takes month, if not years, to observe. Cognition Therapeutics CEO Lisa Ricciardi advocates that, to improve better assess a drug's impact, drug developers must focus on and leverage better biomarkers for quicker assessment.
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Patenting Functionally Claimed Biological Compounds After Amgen V. Sanofi
7/10/2023
Snell & Wilmer attorneys discuss the recent SCOTUS decision to uphold the Federal Circuit's holding that Amgen’s patent claims for functionally claimed antibodies were invalid for failing to meet the enablement requirement. The attorneys share what this means for the industry going forward.
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Targeting SORT1 To Drive Peptide–Drug Conjugates In Oncology
7/3/2023
Peptide-drug conjugates — therapies that generally employ a cleavable or non-cleavable linker to attach a receptor-targeting peptide to a drug payload — have emerged as a potentially viable modality for targeted cancer treatment. How do they work? And how is the glycoprotein SORT1 one of the most promising targets?
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Key Post-Pandemic Trends In Global FDA Observations For Drug Facilities
6/29/2023
These authors undertook a meticulous analysis of FDA drug facility inspection data spanning from July 2021 through May 2023. The resultant trend insights provide powerful resources for understanding areas of regulatory focus and a benchmark for evaluating potential vulnerabilities.
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A Brief Overview Of Epigenetics
6/26/2023
Epigenetics is an emerging domain of scientific research that studies how the environment and behaviors can cause changes that affect the way genes work. This article shares a brief overview of the space.
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A Brief Introduction To Genome Editing
6/21/2023
Genome editing technologies enable removal, addition, or alteration of genetic material at particular locations in the genome. This article provides a brief introduction to the space.
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An Agile Approach To Regulatory Information Management System Transformation
6/20/2023
Life sciences industry regulators have become increasingly focused on data-driven processes as a means of managing marketing authorization submissions. But this requires that your regulatory information management system (RIMS) upgrades are in a state of continuous evolution and are approached holistically.
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The Growing Use Of Antibody Library Technologies In Drug Discovery
6/14/2023
Antibody library technologies enable the screening and identification of antibodies with desired properties (such as high affinity and specificity) for a wide range of targets, including proteins, peptides, small molecules, and even complex cellular structures. Here are the key emerging trends.