Drug Discovery Featured Articles & Applications

  1. Quantification Of T Cell Subsets In Stem Cell Transplant Patients

    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the most effective treatment for patients with high risk and relapsed hematologic malignancies. When donor T cells recognize the host as foreign, they induce an immune response against the host and may cause life-threatening graft-versus-host disease (GvHD), a major complication of allo-HSCT. 

  2. A 19-Color Multiparameter White Blood Cell Panel Designed For The Immunophenotyping Of Normal And Malignant Leukocytes By Flow Cytometry

    Flow cytometry is an important tool for the diagnosis and classification of leukemia. While many leukocyte markers have been identified and are used to determine the exact subtypes of leukemia a patient may have, high-dimensional multicolor analysis has been limited by instrument capabilities. This has often resulted in splitting a valuable limited sample into multiple independent tests to fully define the patient’s phenotype.

  3. Immunotherapy: The Next Frontier For Cancer

    Does the human body have the capability to heal itself? The idea of immunotherapy, harnessing the body’s own immune system to eradicate disease, has moved from the realm of possibility to something much more tangible. Interestingly, this promising therapy is not a new concept and has actually existed for more than 125 years, originating when William Coley, MD introduced the notion that the immune system could be useful in the treatment of cancer. He had observed that bone and soft tissue sarcoma patients experienced remission as a result of a concurrent bacterial infection and began to treat patients with heat-killed streptococcal organisms that he called Coley toxins. The toxins he administered to patients resulted in a 50% near-complete remission rate (Institute for Clinical Immuno-Oncology 2015).

  4. Use of Liquid Biopsy for Cancer Diagnosis and Monitoring

    Liquid biopsy is a noninvasive method used for the diagnosis and monitoring of disease states, including cancer. Instead of physically taking a biopsy of the affected tissue, cell-free DNA (cfDNA), circulating tumor DNA (ctDNA, a subset of cfDNA present only in tumors), or cancer cells in suspension (also known as circulating tumor cells, CTCs) are collected from blood or other fluids.

  5. How Droplet Digital PCR Has Revolutionized Noninvasive Plasma-Based Detection Of Mutations

    MolecularMD is a preferred provider of molecular diagnostic products and services to pharmaceutical and biotechnology drug developers. Our capabilities range from specialty molecular testing performed in our centralized CLIA-certified and CAP-accredited laboratories to development of FDA-approved companion diagnostics.

  6. Commissioner Gottlieb, CAR T-Cells, & The Future Of Rare Disease Therapies

    This article explores some of the policy changes happening now in the regulatory rare disease space as the FDA’s leadership team implements these changes at the agency.

  7. Why Pharma Needs A New Approach To Patient Engagement In Drug Development

    Pharmaceutical companies face many challenges: developing life-changing products that meet the needs of patients, physicians, and payers; adhering to regulatory standards; and managing health technology and payer scrutiny, all while trying to satisfy investors. As drug prices seem to be continually rising, many health plans are shifting more of the cost-sharing burden to patients.  As a result, the patient is becoming more of a “consumer” in the traditional sense.

  8. Integrated Delivery Networks & The Future Of Drug Development

    IDN characteristics can include shared clinical guidelines, a common technology platform, and the ability to jointly negotiate with payers on contracts that may involve financial risk for quality and patient outcomes. Simply put, IDNs are healthcare ecosystems unto themselves. 

  9. Cost Savings And Speed: The Untapped Value Of A Single-Source Solution

    Small and emerging companies face significant challenges in today’s market. This calls for an alternative solution to help them achieve success. One option is a single-source solution, which can eliminate the silos that can often exist in today’s outsourcing paradigm, increasing both communication and speed.

  10. Insights And Tips When Addressing Bioburden Challenges

    This white paper addresses the challenges associated with the bioburden control process involved in making mAbs or other biologicals, as well as the single-use solutions and improved ways of working that manufacturers can use to avoid microbial contamination.