Drug Discovery Featured Articles & Applications

  1. FDA's CBER Issues Final Guidance For CAR T Cell Products 2/15/2024

    The FDA issued the final guidance document, Considerations for the Development of Chimeric Antigen Receptor (CAR) T Cell Products, on January 29. This article shares a useful and thorough summary of the guidance and where it differs (or not) from the earlier draft version of the guidance.

  2. PROTACs And Molecular Glues: Rethinking What Is Possible 2/9/2024

    This article explores the potential of novel small molecule approaches to address undruggable targets in oncology, including PROteolysis TArgeting Chimeras (PROTACs) and molecular glues, and how they work. 

  3. 2024 And Beyond: The State Of Alzheimer's Disease Research And Drug Development 2/7/2024

    The ongoing advancements in both drug delivery and therapeutic strategies underscore a growing wealth of progress in the battle against Alzheimer's disease.

  4. Indo-U.S. Collaboration Can Accelerate Drug Discovery — Here's How 1/30/2024

    Innovation in drug discovery can suppress development costs, ultimately improving patient access. Collaborations between India and the U.S. promise to accelerate that innovation on several fronts.

  5. FDA Draft Guidance On “Rare Diseases: Considerations For The Development Of Drugs And Biological Products” 1/26/2024

    Accenture Applied Life Science Solutions' Raj Bandaru, Ph.D. breaks down, summarizes, and shares detailed insight on the recent FDA Draft Guidance that addresses “Rare Diseases: Considerations for the Development of Drugs and Biological Products.”

  6. Tracking 4 Payload Trends In Drug Delivery Development 1/22/2024

    Amid new research and development in nanocarriers, market attention has shifted toward payloads and enhancing compatibility. This discussion explores the latest trends and includes a research database.

  7. Understanding Undruggable Targets: Challenges And Progress 1/18/2024

    As we continue to discover new treatment approaches, we need to go beyond targeting proteins with well-defined pockets and find other ways to target the undruggable. Two approaches that show promise are PROTACs and molecular glues.

  8. The Benefits Of Using GenAI In Drug Discovery And Preclinical Development 1/17/2024

    The emergence of generative artificial intelligence (GenAI) has the potential to reform early-stage drug discovery and development. Large language models are being harnessed to create novel molecules tailored for specific properties, positioning them as potential drug candidates. It could also unveil previously overlooked therapeutic possibilities. Pharma leaders must ensure they have a sound strategy for this.

  9. Finding New Treatments In Old Therapies 1/12/2024

    Discover the types of repurposed drugs and tips for making them a reality with international healthcare consultant Robert L. Quigley, MD, D.Phil.

  10. A Patient-Centric Approach Built On The Porosome 1/10/2024

    About 85% of disease-causing proteins remain impervious to current therapeutic interventions. One potential pathway to address this problem is the structure in the cell that constitutes its secretory machinery: the porosome.