MaxCyte® Electroporation Enables Efficient Antibody Discovery By Mammalian Display

Efficient antibody discovery hinges on the ability to screen vast libraries and identify candidates with desirable properties. A key challenge in this process is ensuring high sequence diversity and representation during library screening. Mammalian display offers a promising approach for identifying antibodies with strong antigen affinity and favorable biophysical characteristics, which are crucial for successful development.

A study evaluated different electroporation methods for transfecting IgG plasmid libraries in a mammalian display workflow. The findings indicate that MaxCyte electroporation significantly enhances sequence diversity and library coverage, all within a streamlined process. This method also supports scalable and reproducible transfections, allowing for consistent results and the potential to discover superior antibody candidates with optimized resource utilization.

Download the full application note to learn more about how to improve your antibody discovery workflow.