MaxCyte® Enabled Development Of A Landing-Pad CHO Cell Line For Mammalian Display

Mammalian display techniques offer significant advantages over traditional in vitro display technologies, including reduced immunogenicity and improved stability and solubility for candidate antibodies. Developing a monoclonal, high-expressing, single-site landing pad cell line simplifies mammalian display screening by enabling targeted, single-copy sequence integration. This approach removes the need to normalize for variations in transcription that can complicate results from methods like viral transduction or standard transfection.

Learn how a Flp landing pad CHO cell line was developed to facilitate biologic drug discovery through efficient, single-copy integration of candidate sequences, leading to a stable cell line that can be used for rapid mammalian display cell library preparation.