Ultra-High-Throughput Biophysical Screening Of MEK1 Using The Dianthus uHTS Platform

Ultra-high-throughput biophysical screening is crucial for identifying promising drug candidates in early-stage drug discovery. This application note demonstrates how Spectral Shift technology can be used for rapid hit identification with minimal sample consumption. It details a high-throughput biophysical screening campaign targeting MEK1, a critical kinase in cancer pathways, using the Dianthus uHTS platform. The study successfully screened over 5,000 compounds, identifying 62 high-priority hits and validating 28 compounds with strong binding affinities. This approach not only conserves valuable protein resources but also provides a robust and efficient method for accelerating drug discovery efforts.

Access the full application note to learn more about how this technology can enhance your screening workflows.