Downloads
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Self-Contained TFF Cassettes For Diafiltration In A Single Pass
3/13/2024
Explore detailed insights into self-contained tangential flow filtration cassettes for continuous diafiltration with low buffer consumption matching conventional diafiltration performance in one pass.
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Hybrid Modeling Approach For Rapid Clone Selection In Perfusion Processes
3/13/2024
Discover a hybrid modeling approach designed for rapid clone selection in perfusion processes that can help you determine optimal process characteristics and growth conditions, expediting development.
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Identify And Mitigate Absorption Risks With PBPK Modeling
3/12/2024
See how PBPK models combined with custom and off-the-shelf in vitro tools and solubility enhancement expertise can reduce the need for drug product reformulation or repeated preclinical or clinical studies.
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Sterilizing Grade Filter Performance With Biologic Drugs
3/11/2024
Here, we analyze the throughput performance of sterilizing grade filters across moderate-to-high concentrations of mAbs and immunoglobulins and demonstrate how filter selection can impact your process.
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Serial Success With Triumvira's Rob Williamson
3/10/2024
Rob Williamson's mind and hands have shaped more than 20 biotech startups, leading some to IPO and landing others firmly in Big Bio through acquisition by companies like Merck. Hanging around as many successful exits as Williamson has seen, one might become an expert via osmosis. But Williamson isn't passive about honing his vision for progressive therapeutic dealmaking.
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Drugging The Undruggable: Strategies And Future Directions
3/7/2024
Progress with PROTACs and molecular glues hasn’t come without challenges, particularly in identifying the right chemistry starting point for drug development — a process known as hit discovery. This article looks at the role of CRISPR, screening assays, and more.
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8 Key Takeaways Of The Proposed FDA Modernization Act 3.0
3/6/2024
On Feb. 6, 2024, new legislation was introduced in the House of Representatives: the FDA Modernization Act 3.0. It aims to reduce and replace the use of animals in nonclinical research, improve predictivity of nonclinical testing, and potentially reduce drug development times. This article shares an overview. Note that the proposed legislation would still need to go through its course of passing the House and Senate and being signed by the president before becoming a law.
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Producer Cell Line To Elevate Your AAV Production To The Next Level
3/6/2024
Discover a true producer cell line where Rep, Helper, Cap, and the gene of interest are stably integrated into the host cell's genome, requiring only a single induction step to initiate AAV production.
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Exosome Isolation By TFF And Size Exclusion Chromatography
3/6/2024
Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.
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A Scalable Single-Use Two-Step pDNA Purification Process
3/6/2024
Evaluate the performance of a single-use two-step plasmid purification process, and see how it compares to the existing three-step purification method.