Downloads

  1. Emerging Fields In Immunology: New Frontiers For Therapeutic Discovery 9/1/2026

    Immunology has expanded into several specialized domains as our understanding of the immune system has grown.

  2. Preclinical Genome Editing Risk Assessment Services 8/31/2026

    Regulatory-aligned off-target risk assessment for genome editing programs, from early guide RNA screening through IND-enabling confirmation studies, structured to support FDA submission requirements.

  3. Turning Pediatric Cancer Discoveries Into Medicines Requires Better Connections 8/27/2026

    Promising pediatric cancer science often stalls before patients benefit. David Adler explains how better connections could change that.

  4. It Is Time To Require Human-Relevant Efficacy Evidence Before First-In-Human Trials 8/26/2026

    Why, when human-relevant evidence of likely efficacy can be generated before a trial begins, is it not evaluated before patients are exposed?

  5. From Cell State Reprogramming To The Clinic: Turning The Regulatory Genome Into RNA Medicines (Pt. 2) 8/26/2026

    Ounzain discusses how regulatory genome biology is being translated into drug discovery, from identifying lncRNA targets to building clinically relevant therapeutics and more.

  6. Novel Approach To Cancer Explores Severing Its Genetic Supply Line 8/25/2026

    Gene ablation represents an important and novel approach to treating cancer. One company is focusing on disabling the NRF2 gene to starve cancer cells.

  7. Target Transcription Factor States, Not Pockets 8/21/2026

    Transcription factors expose broad protein–DNA and protein–protein interfaces, contain intrinsically disordered regions, and exchange partners as cellular context changes.

  8. Potency Is Not An Exposure Strategy 8/20/2026

    Potency is measured in an assay; exposure is achieved in an organism. Confusing the two is a category error that still shapes hit selection.

  9. Maintain Performance And Reduce Downtime 8/19/2026

    See how modernizing aging chromatography system controls can reduce downtime risk, improve serviceability, and support validated workflows through updated hardware and operating systems.

  10. Drugging The tRNA Control System 8/19/2026

    Drug discovery has usually treated transfer RNA as cellular infrastructure: indispensable, highly conserved, and therefore dangerous to perturb. That description is accurate but incomplete.