Unlocking Challenging Targets With Macrocycle DNA-Encoded Libraries

Many high-value drug targets resist conventional small-molecule approaches because their binding surfaces are broader and more complex. Macrocycles can help researchers address these challenges by providing access to differentiated chemical space and new opportunities for molecular recognition. Yet identifying productive starting points requires more than generating hits. Researchers must also understand which compounds show meaningful structure–activity relationships and possess the qualities needed for further development.

Learn what makes macrocycles valuable, how DEL screening reveals relationships between structure and activity, and how selected hits can be translated into potent, selective compounds.