Drug Discovery Featured Articles & Applications

  1. Key Considerations For Developing Next-Generation Antibody-Drug Conjugates 5/11/2023

    Fourteen antibody-drug conjugates (ADCs) have been approved globally for cancer indications so far. This article shares considerations for complementing target with antibody subtype, optimizing format for half-life functionality, and delivering payloads with diverse MOA.

  2. India’s CROs & CDMOs Come Of Age In The Global Marketplace 5/4/2023

    Most of the top 10 pharmaceutical companies and many large biotech companies today get a portion of their preclinical/clinical research, drug development, and/or manufacturing done in India. While a low price is the initial attraction, there are additional factors that can be more meaningful.

  3. 5 Characteristics Of The Automated Microbiology Lab Of The Future 4/24/2023

    The modern microbiology laboratory is starting to look very different from the laboratory of 10 years ago, and it will continue to evolve in the next few years. There are a number of innovations being implemented now or are in progress that can signal the path that many microbiology laboratories will follow.

  4. Risk-Based Strategies For Revalidating Bio/Pharma Equipment & Systems 4/20/2023

    While equipment and systems validation is a regulatory requirement, it would take thousands of annual tests to retest all equipment and systems. BioPhorum shares risk-based approaches to new product introduction, controlled temperature chambers, sterilization processes, and more.

  5. Congressional Changes For Orphan Drug Approvals? 4/18/2023

    Lawmakers are stepping in to increase the number of rare disease and orphan drug experts who sit on advisory committees. As it stands now, advisory committees can include experts who simply have a broad understanding of the overall disease state.

  6. Organ-On-Chip Devices Show Promise In Drug Discovery 4/10/2023

    There is growing interest in the potential uses for organ-on-chip devices as a novel tool for drug discovery. These devices offer a unique platform that mimics the physiology and function of human organs, providing a more accurate representation of human biology than traditional cell culture systems.

  7. Pharmaceutical Company Innovation By The Numbers 4/6/2023

    Clarivate has published its 2023 list of the Top 100 Global Innovators, identifying the companies and institutions globally that have pushed the boundaries of technology and applied knowledge the furthest. To define “innovation” in this context, Clarivate uses global invention data, which includes patent applications and issued/granted patents.

  8. Add Biologics Manufacturing Efficiency With Design Of Experiments, Part 2 4/5/2023

    By reducing the total number of experiments, design of experiments methods streamline process optimization. With fewer tests, drug makers can spend less of their budgets on screening and more on process characterization.

  9. Forming Meaningful Pharma-Academia Partnerships 4/3/2023

    In large pharma, R&D investment is increasingly expensive. In academia, there is pressure to produce high-profile science for the improvement of public health. Collaboration between industry and academia is key to innovation and addressing the unmet needs of patients.

  10. Increase In FDA Inspections + Whistleblower Complaints = Heightened Compliance Scrutiny 3/27/2023

    We are seeing a significant increase in manufacturing facility inspections by the FDA and other health authorities globally. We are also seeing an uptick in whistleblower complaints. Why? And how can you navigate it? This article examines the issue.