Drug Discovery Featured Articles & Applications

  1. The Scientist’s Perspective On Single Supplier CDMOs

    In the pharmaceutical industry, speed is of the essence. As drug developers face increasing pressure to get formulations to market as efficiently as possible, the CDMO industry is evolving to meet this need. The Patheon OneSource™ model exemplifies the benefits of an end-to-end supply chain model for pharmaceutical and biopharmaceutical clients by accelerating time to market, adding cost savings, and putting formulations on the path toward regulatory success. Following a CPhI North America panel discussion about single-vendor CDMOs, Anil Kane, executive director and global head of formulation sciences at Patheon, discusses his views on this subject.

  2. The Supply Chain Executive’s Perspective On Single-Supplier CDMOs

    A single vendor offers access to a network of experts across several disciplines who can share knowledge about a project as it moves from phase to phase, thus helping to navigate its path toward commercial success. Following a CPhI North America panel about single-source CDMOs, Paul Nelson, vice president of supply chain and R&D at Amring Pharmaceuticals, discusses his experience with single-source CDMOs.

  3. Medical Device Manufacturer Improves Product Quality Control

    Osstem Implant adopted an integrated business framework that helps it eliminate traditionally disconnected processes and data and increase the efficiency and accuracy of its product quality control.

  4. Data Solutions For CMOs Working With Sponsor Organizations

    CMOs can empower their sponsors or customers to conduct many of these activities on their own products or processes through better data transparency.

  5. Quality by Design (QbD) In Pharmaceutical Development

    Quality by Design (QbD) is a systematic approach to product development that begins with predefined objectives and emphasizes product and process understanding and controls based on sound science and quality risk management (ICH Q8). The emphasis of QbD began with the recognition that increased testing does not essentially improve product quality; however, quality must be built into the product.

  6. Biggest Mistake You Can Make With Continuous Manufacturing And The FDA

    To allay fears about continuous manufacturing changes, utilize the valuable tools and resources that the FDA has created. Seeking the agency's insight early will also give you a clearer path for success.

  7. Advancements in Protein Purification Workflows Speed Up Research

    When testing new drug therapies, it is essential to know the identity of the protein being tested. Whether that protein is the drug itself or the target for the drug, researchers must be absolutely sure of its identity and purity. Though many methods are used in the process of obtaining pure proteins, chromatography is commonly used to separate complex biological mixtures and isolate proteins of interest prior to downstream characterization.

  8. Virtue Is Harmony: Using Lab Data Automation To Break Down The Silos In Pharma R&D

    In a scenario where manufacturing processes move to a continuous flow, analyzers are producing data simultaneously, necessitating real-time processing and cloud-based tools for data management.

  9. Fighting The Opioid Epidemic: How Grünenthal’s Abuse-Deterrent Technology Contributes

    While the wider use of opioids has led to many benefits for patients in pain, it also has led to higher incidences of misuse, abuse, and development of opioid addiction. To address this issue without preventing legitimate patients from receiving their necessary medication, Grünenthal set out to create an abuse-deterrent formulation with a technology that creates a physico-chemical barrier to abuse and, as a result, safeguards patients from the battle of addiction.

  10. Consultants’ Guide To Flexible Biomanufacturing Solutions

    Consultants play a critical role in ensuring the long-term success of small biopharmaceutical companies, though much of their work happens behind the scenes. From lifecycle planning to marketing advice, consultants help fill gaps in knowledge while having their fingers on the pulse of new production strategies that might be a fit for clients.