Drug Discovery Featured Articles & Applications

1. Targeting GRIN Genes In Drug Development To Treat Neurodevelopment Disorders 8/28/2025

   The ability to precisely control the activity of NMDA receptors could play a role in the treatment of a range of neurodevelopmental disorders. We caught up with GRIN Therapeutics' chief medical officer to discuss drug development.

2. Can America's Retreat On mRNA Be Europe's Opportunity? 8/28/2025

   With HHS winding down mRNA vaccine development under BARDA, could Europe seize the opportunity to lead in mRNA innovation? Exploring the policy shift's implications.

3. The OBBBA: Biopharmas Unlock R&D Expensing, Global Tax Efficiencies 8/28/2025

   Biopharma innovators may soon see major tax breaks thanks to the One Big Beautiful Bill Act (OBBBA). The new legislation introduces targeted tax incentives designed to strengthen domestic R&D and capital investment.

4. AI Plus The Scientific Method Might Reinvent Drug Discovery 8/26/2025

   In the absence of good data, clear hypotheses, and experimental feedback, AI’s outputs can quickly become unreliable. The solution lies in integrating AI and the scientific method.

5. Developing Interleukin-2 For Cell Therapies: Key Considerations 8/20/2025

   By promoting cell expansion, survival, and functionality, interleukins help optimize therapeutic outcomes in cancer immunotherapy and regenerative medicine. Let’s look closer and compare ex vivo and in vivo approaches.

6. Unlocking The Pharmacological Potential Of Antibodies 8/20/2025

   Abalone Bio's CEO and co-founder, Richard Yu, Ph.D., explains the company's Functional Antibody Selection Technology (FAST) platform and its approach to developing a pipeline of G protein-coupled receptor (GPCR) mAbs.

7. Weight Of Evidence Assessments For Carcinogenicity Studies: An Overview 8/20/2025

   Carcinogenicity assessments often rely heavily on two-year rodent bioassays. The weight of evidence (WoE) approach seeks to streamline this process, combining thorough science with regulatory practicality.

8. Advancing CAR T Cell Therapy with Logic Gate Engineering 8/19/2025

   Logic gating applies Boolean logic principles to CAR T cell design to improve precision and minimize collateral damage.

9. Oligos Step Into The Spotlight: A Growing Force In Genetic Medicine 8/18/2025

   Oligonucleotide therapeutics are experiencing a new wave of momentum. As the science evolves and the market opportunity expands, the landscape is poised for continued growth and diversification.

10. From Concept To Confidence: A Collaborative Path To Validating NAMs 8/15/2025

    On August 1, 2025, the Foundation for the National Institutes of Health (FNIH) released a Request for Information (RFI) inviting proposals for pilot projects to accelerate the development, validation, and regulatory acceptance of New Approach Methodologies (NAMs). For drug developers, participating in this process offers not only scientific collaboration but also the potential to co-develop regulatory-grade NAMs aligned with FDA and NIH priorities.