Drug Discovery Featured Articles & Applications

1. The Unlikely Weapon Against Fentanyl: Your Immune System 12/23/2025

   ARMR Sciences Inc. has developed a vaccine designed with a novel adjuvant, dmLT, to neutralize fentanyl in the bloodstream before it reaches the central nervous system and binds to μ-opioid receptors (MORs). 

2. Partnering For Progress: Funding The Future Of Rare Disease Research 12/23/2025

   We caught up with Matthew Anderson, MD, Ph.D., to discuss the Oxford-Harrington Rare Disease Centre’s research efforts in drug discovery.

3. In Vivo LNP-Engineered Cytokine-Armored CAR Cells For Solid Tumors 12/23/2025

   By injecting lipid-based nanoparticles encapsulating mRNA and encoding the CAR directly into the bloodstream, developers can effectively reprogram the patient's own immune cells in situ.

4. Small Molecule Enzyme Mimetics In Age-Related Neurodegeneration 12/19/2025

   We caught up with Jack Scannell, CEO of Etheros, to discuss the company’s work to create small molecule enzyme mimetics to tackle age-related neurodegeneration, inflammation, and potentially slow human aging.

5. The Next Frontier In Drug Discovery: Reinventing Old Platforms To Solve New Problems 12/19/2025

   By combining proven technologies with new biological targets, we can create therapies that retain known safety while addressing emerging or previously intractable diseases.

6. 2025's Top 5 Drug Discovery Highlights And How To Stay Ahead In 2026 12/15/2025

   Drug Discovery Online's 2025 Top 5 most consequential shifts affecting this rapidly evolving field, including NAMs, AI, Individualized Therapies, Innovating China, and Early-stage Funding Volatility.

7. Avoiding Protein Purification Artifacts That Still Undermine Drug Design 12/15/2025

   Protein purification artifacts are common technical issues, but when they go unnoticed, they can distort structural data and later lead to unreliable experimental results.

8. Designing Drugs For Women: Closing The Therapeutic Gap 12/12/2025

   Women’s health remains underdeveloped in drug innovation. Growing momentum across policy, science, and funding creates an opportunity to better align drug discovery with women’s health needs.

9. Small Cells, Big Shifts: Recent Advances In Targeting Small Cell Lung Cancer 12/11/2025

   Therapeutic progress in small cell lung cancer has been limited, with meaningful advances emerging only in the past two years. We discuss these new developments and consider the future treatment paradigm.

10. CROs In Early Drug Discovery, Part 3: Budgets, Timelines, And Avoiding Pitfalls 12/10/2025

    Part 3 of this series covers managing budgets, timelines, and avoiding operational pitfalls.