Drug Discovery Featured Articles & Applications

1. Expanding A Single Mechanism Through Genetic Logic And Clinical Observation 9/12/2025

   With the right biology, a single mechanism can open multiple clinically meaningful avenues for oncology drug development. Step Pharma CEO discusses their clinical development programs for oncology.

2. The Death Of A Dogma: David Baltimore And Lessons For Modern Drug Discovery 9/11/2025

   Nobel laureate, David Baltimore passed away at 87 years old, on September 6, 2025. He was widely regarded as a scientific visionary who at just 37, co-discovered reverse transcriptase, an enzyme that flipped molecular biology on its head by showing that genetic information could flow from RNA back to DNA, not just the other way around. 

3. Building Robust AI Systems For Drug Discovery Requires Epistemic Humility 9/10/2025

   The future of AI in drug discovery lies not in replacing human judgment but in creating systems that enhance it by combining the pattern recognition power of machines with epistemic humility.

4. Redesigning Oncology Trials Around Tumor Vulnerability: The Rise of WEE1 And DDR Strategies 9/8/2025

   As clinical progress with DNA damage response (DDR) continues to evolve, research must respond with adaptive models, smarter combinations, and biomarker-informed patient selection.

5. Targeting GRIN Genes In Drug Development To Treat Neurodevelopment Disorders 8/28/2025

   The ability to precisely control the activity of NMDA receptors could play a role in the treatment of a range of neurodevelopmental disorders. We caught up with GRIN Therapeutics' chief medical officer to discuss drug development.

6. Can America's Retreat On mRNA Be Europe's Opportunity? 8/28/2025

   With HHS winding down mRNA vaccine development under BARDA, could Europe seize the opportunity to lead in mRNA innovation? Exploring the policy shift's implications.

7. The OBBBA: Biopharmas Unlock R&D Expensing, Global Tax Efficiencies 8/28/2025

   Biopharma innovators may soon see major tax breaks thanks to the One Big Beautiful Bill Act (OBBBA). The new legislation introduces targeted tax incentives designed to strengthen domestic R&D and capital investment.

8. AI Plus The Scientific Method Might Reinvent Drug Discovery 8/26/2025

   In the absence of good data, clear hypotheses, and experimental feedback, AI’s outputs can quickly become unreliable. The solution lies in integrating AI and the scientific method.

9. Developing Interleukin-2 For Cell Therapies: Key Considerations 8/20/2025

   By promoting cell expansion, survival, and functionality, interleukins help optimize therapeutic outcomes in cancer immunotherapy and regenerative medicine. Let’s look closer and compare ex vivo and in vivo approaches.

10. Unlocking The Pharmacological Potential Of Antibodies 8/20/2025

    Abalone Bio's CEO and co-founder, Richard Yu, Ph.D., explains the company's Functional Antibody Selection Technology (FAST) platform and its approach to developing a pipeline of G protein-coupled receptor (GPCR) mAbs.