Selecting A Platform Filter For High Concentration mAbs

By Stephanie Lemoult, Fujifilm Diosynth Biotechnologies Denmark ApS, and Lukas C. B. Gade, Patrícia Raleiras, and Alexandra Guerra, Cytiva

Fujifilm Diosynth Biotechnologies, a leading Contract Development and Manufacturing Organization (CDMO) renowned for its expertise in the formulation and final filling stages of drug product manufacture, embarked on an evaluation of our Supor™ Prime filter. This evaluation involved challenging simulant solutions that were characterized by high viscosity and a propensity for filter fouling. Through rigorous experimental testing, Fujifilm Diosynth Biotechnologies generated data that confirmed the superior performance of Supor™ Prime sterilizing grade filters. These filters demonstrated twice the throughput and average flux compared to traditional PVDF filters.

Learn more about this remarkable performance that makes Supor™ Prime filters an excellent candidate for use in both the bioburden reduction steps and the final filtration stages of highly viscous protein solutions to ensure efficient and reliable filtration throughout the biopharmaceutical manufacturing process.