Drug Discovery Featured Articles & Applications

1. From Undruggable To Druggable: The Science Reshaping Small Molecule Discovery 7/1/2025

   For decades, most biologically validated disease-relevant protein targets have remained chemically inaccessible, thereby resisting conventional small molecule approaches. But now, a new wave of scientific innovation is paving a way forward.

2. Five Takeaways from BIO 2025 and Why You Should Stay Tuned 6/26/2025

   New chief editor of Drug Discovery Online shares insights from BIO 2025’s global biotech gathering and spotlights the impacts to early-stage drug research.

3. From Matrix To Medicine: New Frontiers In Treating Pulmonary Fibrosis And PH 6/25/2025

   Halo Biosciences is building a pipeline based on novel insights into how extracellular matrix dysregulation drives disease. We caught up with its leaders to discuss their approach to drug targeting and early development.

4. Tackling Antimicrobial Resistance With Precision Targeting 6/20/2025

   TAXIS Pharmaceuticals is developing therapies to combat antimicrobial resistance. We caught up with the company's CEO and CSO to discuss their approach to early R&D.

5. Formulation Development Of A JAK1 Inhibitor Extended-Release Tablet 6/19/2025

   This scientific article presents a summary of the formulation development strategy of a JAK1 inhibitor extended-release tablet, with a focus on experimental design, data interpretation, and formulation decision-making.

6. A Guide To Designing mRNA Medicines 6/10/2025

   A poorly designed mRNA sequence can create ongoing difficulties during downstream clinical development and manufacture. Let's take a closer look at strategies and design software that you can employ.

7. Bracing For The Impact Of The Federal Workforce Reduction 6/9/2025

   The federal workforce reductions pose significant challenges for the life sciences industry, particularly for R&D, supply chain oversight, and industry workforce development.

8. Radiopharmaceuticals: Navigating FDA Guidance And CMC Considerations 6/2/2025

   The unique nature of radiopharmaceuticals necessitates specialized regulatory considerations, particularly for chemistry, manufacturing, and controls (CMC).

9. Designing Our Way Toward Circular RNA Medicines With AI 5/21/2025

   The closed-loop structure of circular RNA can offer sustained, durable expression. We caught up with Sail Biomedicines' Kerry Benenato and Rajesh Ramaswamy to chat about ways to leverage AI for design/engineering.

10. Will Genome Modifications Define Next-Gen AAV Vectors? 5/20/2025

    AAV vectors composed of naturally occurring capsids are suboptimal. Gentle genetic alterations hold promise for safer, more efficient therapy.