Drug Discovery Featured Articles & Applications

1. Small Molecule Drug Discovery: Can AI Do It All? 4/27/2022

   The hope is that AI can solve the single most challenging problem at the heart of modern drug discovery: the reliable prediction of novel small molecule drugs that potently bind to a disease-causing protein and alter its function. This article discusses the challenges and how we can position ourselves to navigate them.

2. The Current Landscape Of mRNA Vaccines In Clinical Research 3/17/2022

   With the Pfizer-BioNTech and the Moderna vaccines, messenger RNA (mRNA) vaccines made global headlines in 2021 in the fight against COVID-19. This article shares how mRNA vaccines currently in clinical research and clinical trials may be soon used to fight HIV-1, herpes, cancer, and more.

3. Biopharma Deal-Making In 2022: Key Trends 3/11/2022

   Strategic partnerships and alliances in biopharma have become an even more important means of accessing new capabilities. This article examines key recent trends in biopharma deal-making and M&A, and how those will inform related activities in 2022.

4. What’s The Role Of Intuition When Making QRM Decisions? 2/28/2022

   In Part 1 of this 2-part series, this author explained how to effectively set up your quality risk management (QRM) program for pharma and medical devices. In this article, he explains how to implement that program. For such a numbers-based field, there is still an important role for using your intuition to make QRM decisions.

5. What Are Risk Appetite & Risk Tolerance In Pharma & Medical Devices? 2/23/2022

   This article describes and differentiates risk appetite and risk tolerance and discusses why these two concepts are foundational to how we make risk-based decisions in pharma and medical devices. Also covered are a spectrum for risk appetite, best practices for risk communication, and events and conditions that can shape risk appetite and tolerance.

6. How To Set Up An Effective Quality Risk Management Program 2/16/2022

   The author of this article has taught courses on quality risk management (QRM) and its implementation as well as seen it in action in many companies. This article, Part 1 of a 2-part series, shares some of his observations and lessons learned in setting up an effective QRM program.

7. Pharmaceutical Quality Compliance In 2022: Data Is Paramount 2/11/2022

   Pharma quality and compliance leaders must anticipate potential manufacturing issues before they happen by leveraging risk-based methodologies, continuously monitoring their systems, and tracking the profusion of data generated during the process. This article outlines the potential of data and analytics to improve quality performance.

8. The Talent Shortage In Biopharma Demands A Creative Solution 2/2/2022

   The demand for new talent in the biotech industry was already reaching new heights before the COVID pandemic, and now it is even more obvious. Complicating the dilemma is the move toward Pharma 4.0. The industry will need talent that can operate in new business models that are more complex.

9. Sex Matters… In Preclinical Drug Development? 1/18/2022

   In safety pharmacology studies investigating short-term side effects on physiological functions, the scientist is obliged to “consider” sex in the study design of animal models. This article also shares the differences in anxiety and depression in human males and females.

10. Can Anti-TNF Treat Post-operative Cognitive Decline? New Clinical Research Investigates 1/6/2022

    People who suffer from post-operative cognitive decline can develop difficulty remembering things and performing daily tasks, and may possibly end up in nursing homes. There are no existing therapies. However, 180 Life Sciences believes it has a novel understanding of how to treat it.