Drug Discovery Featured Articles & Applications

  1. Can Your Clinical Supply Chain Pass The Brexit Pressure Test?

    - Clinical trial sponsors and clinical supply vendors must fully consider all attributes of their supply chains to ensure continuity of supply post-Brexit. This whitepaper outlines many questions that sponsors and vendors alike should ask

  2. Are Today’s Processes Efficient Enough For The Future Of Vaccine And Viral Vector Production?

    By recognizing the limitations of today’s production processes, the industry may be able to overcome the challenges, complexity, and high cost of manufacturing vaccines and viral vector-based therapies.

  3. The Importance of Proactive Clinical Returns Planning

    Help sponsors design a more holistic strategy to their managing the clinical supply returns process.

  4. Strategies for Efficient Clinical Supply Management and Forecasting

    Engaging clinical supply management and forecasting adds value by evaluating different response strategies and contingency plans and can identify supply solutions that minimize or even potentially avoid supply chain disruptions.

  5. Avoiding Delays In Clinical Supply

    How sponsors can work effectively with clinical suppliers for accurate forecasting and comparator sourcing to avoid delays in clinical supply.

  6. Recent Developments In ADC Technology: A Harbinger Of Future Clinical Trends

    The ADC field is in a transitional period. Older approaches to conjugate composition and dosing regimens still dominate the ADC clinical pipeline, but preclinical work is driving a rapid evolution in how we strategize to improve efficacy and reduce toxicity towards better therapeutic outcomes. In an indication of future directions for the field, antibody conjugates bearing non-cytotoxic small molecule payloads are being developed to reduce side effects associated with treatment of chronic diseases.

  7. Accelerate Complex Molecule Development by Optimizing Chemical Synthesis and Formulation

    The importance of optimizing the chemical synthesis and formulation processes in complex molecule development.

  8. Improved Bioavailability Of Trio Medicines In 12 Weeks

    Learn how a structured 3-step approach can help overcome the challenge of molecular characterization and a limited budget.

  9. Modular Approaches For Diverse Molecules: Reinventing Smart Bioprocessing

    Smart bioprocessing uses bioinformatics, lab-scale processing, and analytics to create efficient and cost-effective production processes that can be verified at lab-scale before scale-up.

  10. Efficient Purification Of The Pertussis Antigens Toxin, Filamentous Haemagglutinin, And Pertactin In Chromatography Workflows

    Read how this method resulted in higher purity and yield than what can be expected from a purification process based on salt precipitations and sucrose gradient centrifugation.