Drug Discovery App CS WP

  1. Predictive Modeling Of Viscosity Behavior Using Artificial Neural Networks 9/11/2023

    Discover a modeling approach employing artificial neural networks (ANNs) using experimental factors combined with simulation-derived parameters plus viscosity data from 27 highly concentrated (180 mg/ mL) mAbs.

  2. Sterile Filtration And Quality Risk Management 8/31/2023

    During the manufacture of sterile products, process control is essential. Here, we explore the role of filtration for bioburden control in quality risk management and contamination control strategies, EU GMP Annex 1, and more.

  3. Recommendations For Successful IND Approval Of RNA-LNP Drugs 8/22/2023

    The existing regulatory system is ambiguous for RNA therapeutics. Leverage this Investigational New Drug (IND) guide to help accelerate and strengthen the process IND filing of novel nanomedicines.

  4. COGs Process Economics For Autologous Cell Therapy 8/11/2023

    Analyze the cost distribution over time for autologous CAR T therapy manufacturing using process economics and insights from scientists and R&D. Discover how cell therapy manufacturers can combat these costs.

  5. Standardize Scale-Up And Reduce Time To Market With Mixing Cartridges 7/21/2023

    Despite the momentum of the RNA-LNP therapeutic market, significant manufacturing challenges remain in the development of RNA-based vaccines and therapeutics. Learn how NxGen™ mixing can solve three key challenges.

  6. Alkaline Stability Of Modern Protein A Chromatography Resins 7/12/2023

    Explore results from a resin lifetime study with over 150 cycles, using clarified cell harvest in every cycle, which has been performed to evaluate the alkaline stability of three protein A resins.

  7. Protein L Affinity Resin Is Ready To Move To Manufacturing 7/12/2023

    Discover a protein L affinity chromatography resin that is well suited for use in biomanufacturing and offers increased binding capacities compared to other resins.

  8. AAV Full/Empty Capsid Separation Using Mechanistic Modeling 5/1/2023

    In this study, we used mechanistic modeling to investigate how AAV-resin interactions are affected when MgCl2 is used as an elution additive.

  9. Recombinant Protein Purification Optimization With HIC 5/1/2023

    A step-by-step high-throughput process development (HTPD) workflow to determine the optimal resin and initial conditions for hydrophobic interaction chromatography (HIC).

  10. Alkaline Stability Of Fc And VH3 Binding In Protein A Resins 5/1/2023

    In this study, we looked at how different antibody binding sites of a protein A ligand are affected by cleaning in place (CIP).