There is a growing demand for closed and automated lentiviral transduction steps in CAR T cell therapy workflows. Learn about a potential solution to address this unmet need.
Combining high productivity chromatography methods and SU affinity membranes deliver a viable alternative to the current packed bed Protein A capture techniques for intensified purification of mAbs up to commercial production scale.
Explore a stepwise approach for integrating process intensification principles into an existing process to increase productivity, reduce costs, and improve process sustainability.
We describe how intensifying two chromatography polishing steps by developing unit operations using Sartobind® Q and CMM HyperCel saves buffer volumes and accelerates the downstream process.
Considering affinity and avidity early in assay design can ensure the desired assay parameters are achieved. Learn about affinity and avidity and how to recognize and resolve issues that may arise.
Learn about the drug development hurdles that must be overcome to deliver on the promise of mRNA.
Explore data demonstrating the successful engineering of a single-use tangential flow filtration system designed to meet the specific requirements of ADC processes.
Explore the challenges faced by a large CDMO as well as the solutions that were provided to achieve significant time savings, cost savings, and the removal of a major downstream process limitation.
See how enhanced T cell expansion as well as the generation of an early-differentiated phenotype can be achieved using a cell culture medium for T cells and cytokines, in a static bioreactor system.
Here, we demonstrate a rapid method for the separation of empty and full AAV8 particles by linear gradient elution on CIMmultus® QA monoliths with 80% recovery.