Drug Discovery App CS WP

  1. Antibody Structure Modeling With Discovery Studio 11/24/2021

    Improving the understanding of critical properties of antibodies as early as possible in development and formulation will impact speed and total cost to market. When 3D structures are not available from X-RAY or NMR, 3D in silico models generated are the solution.

  2. Tackling NTDs At Collaborations Pharmaceuticals - Streamlining Drug Repurposing 11/24/2021

    The diversity of the pathogens implicated in NTDs, the relative complexity of their life cycles and their poor tractability in the lab have resulted in a lack of potential therapeutic targets and candidates. By repurposing existing high throughput screening (HTS) data for Ebola and Chagas Disease to create machine learning models which could screen libraries for potential active compounds, especially compounds previously approved by the US FDA for other diseases, they were able to provide safe and efficacious treatments for those who need them most.

  3. Integrated Predictive Sciences Solutions To Accelerate Drug Discovery And Innovation 11/24/2021

    Learn how having the right predictive sciences capabilities integrated into R&D work flows delivers a scientific decision support environment that reduces time and expense, improves quality, enhances collaboration and accelerates innovation in bringing new drugs to market.

  4. Implementing An Integrated Quality System To Support Business Growth 11/15/2021

    A multinational pharmaceutical company with world-wide commercial operations provides contract manufacturing, product development and clinical services to third-party customers. Geographically-dispersed and disconnected business units demanded virtual collaborations that were not easy to support, and many processes throughout the company were manual and disconnected, hindering productivity and collaboration. The company implemented a solution to enable them to deliver high quality, compliant products in an efficient manner.

  5. Liquid-Liquid Mixing Without Vortex Formation 11/12/2021

    This application note describes liquid-liquid homogenization conditions which meet these requirements at various filling levels in four types of mixers.

  6. Trends In Single-Use Mixing Technologies 11/12/2021

    Here we present an overview of the current mixing technology landscape driven by the need for versatile biomanufacturing platforms with increased productivity.

  7. In Vitro Dissolution Methodologies For Amorphous Solid Dispersions 10/25/2021

    With the availability of so many types of in vitro dissolution tests, how do you determine which one will be most effective in predicting in vivo performance of your BCS II or IV drug product?

  8. Capture Of Histidine-Tagged Molecules Using Biacore His Capture Kit 10/21/2021

    Find recommendations for immobilization of histidine-tagged molecules (ligands) by capture to an anti-histidine antibody covalently coupled to a sensor chip surface.

  9. Combining Ambr 15 Cell Culture With Octet Titer Measurements 10/20/2021

    This platform is an analytical instrument that can easily be implemented in cell line development labs to facilitate rapid determination of product yield.

  10. Quality by Design (QbD) for Adeno-Associated Virus (AAV) 10/14/2021

    CMC is but one obstacle to gene therapy regulatory approval. Here we review a framework for QbD assessment of AAV products within the Chemistry Manufacturing and Controls documentation.