Drug Discovery App CS WP

  1. Complete Structural Elucidation Of Lipids In A Single Experiment Using Electron Activated Dissociation (EAD) 5/24/2022

    Here, electron activated dissociation (EAD) on the ZenoTOF 7600 system is used for the complete structural elucidation of glycerophospholipids, sphingolipids, and acylglycerols in a single experiment.

  2. Orthogonal Fragmentation Mechanism Enables New Levels Of Metabolite Characterization 5/10/2022

    Fragmentation is required to provide structural information about metabolites during drug discovery. Here, two orthogonal fragmentation techniques are compared to determine the in vitro metabolism of the drug darunavir.

  3. Tunable Electron Activated Dissociation (EAD) MS/MS To Preserve Particularly Labile Post-Translational Modifications 5/10/2022

    Post-translational modifications (PTMs) are important players in a diverse group of functions that include protein conformation and signaling. This application note studies the site-localization of malonylated peptides using the SCIEX ZenoTOF 7600 system.

  4. Rapid And Reproducible Parallel Processing Of Charge Heterogeneity Analysis Of Protein Therapeutics 5/4/2022

    In this technical note, we demonstrate parallel, highly reproducible capillary isoelectric focusing analysis using a multi-capillary separation approach to accelerate analysis time.

  5. Ensure High Quantity And Quality Of Isolated Bacterial Ribonucleic Acid (RNA) 4/29/2022

    In this scientific brief we evaluate the performance of the the Pall Nucleic acid binding (NAB) Nanosep centrifugal device for nucleic acid isolation.

  6. Flexibility And High-Quality Extraction Of Genomic DNA And RNA From Yeast, Saccharomyces Cerevisiae 4/29/2022

    In this report, we analyze the quality and quantity of gDNA as well as RNA from S. cerevisiae with Pall NAB Nanosep centrifugal devices in comparison with a renowned commercial brand.

  7. How Syringe Filtration With Integrated Prefilter Technology Improves HPLC Performance And Throughput 4/29/2022

    In this article we review how particulate removal through filtration effects column life and how to handle difficult to filter samples.

  8. Nucleases - Are They A Problem For NAB Nanosep® Centrifugal Devices? 4/29/2022

    We examine whether the sample tubes and collection tubes of the NAB Nanosep centrifugal devices contain detectable amounts of DNase or RNase.

  9. How High-Performance Syringe Filters Extend The Life Of Analytic Instruments And Columns 4/28/2022

    This scientific brief reviews how high-performance syringe filters protect and extend the life of analytical HPLC and UHPLC instruments and columns.

  10. DNA Purification From PCR Or Agarose Gels 4/28/2022

    This study assesses the use of NAB Nanosep centrifugal devices with commercially available reagents for PCR or agarose gel cleanup.