Drug Discovery App CS WP
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Complete Structural Elucidation Of Lipids In A Single Experiment Using Electron Activated Dissociation (EAD)
5/24/2022
Here, electron activated dissociation (EAD) on the ZenoTOF 7600 system is used for the complete structural elucidation of glycerophospholipids, sphingolipids, and acylglycerols in a single experiment.
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Orthogonal Fragmentation Mechanism Enables New Levels Of Metabolite Characterization
5/10/2022
Fragmentation is required to provide structural information about metabolites during drug discovery. Here, two orthogonal fragmentation techniques are compared to determine the in vitro metabolism of the drug darunavir.
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Tunable Electron Activated Dissociation (EAD) MS/MS To Preserve Particularly Labile Post-Translational Modifications
5/10/2022
Post-translational modifications (PTMs) are important players in a diverse group of functions that include protein conformation and signaling. This application note studies the site-localization of malonylated peptides using the SCIEX ZenoTOF 7600 system.
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Rapid And Reproducible Parallel Processing Of Charge Heterogeneity Analysis Of Protein Therapeutics
5/4/2022
In this technical note, we demonstrate parallel, highly reproducible capillary isoelectric focusing analysis using a multi-capillary separation approach to accelerate analysis time.
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Ensure High Quantity And Quality Of Isolated Bacterial Ribonucleic Acid (RNA)
4/29/2022
In this scientific brief we evaluate the performance of the the Pall Nucleic acid binding (NAB) Nanosep centrifugal device for nucleic acid isolation.
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Flexibility And High-Quality Extraction Of Genomic DNA And RNA From Yeast, Saccharomyces Cerevisiae
4/29/2022
In this report, we analyze the quality and quantity of gDNA as well as RNA from S. cerevisiae with Pall NAB Nanosep centrifugal devices in comparison with a renowned commercial brand.
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How Syringe Filtration With Integrated Prefilter Technology Improves HPLC Performance And Throughput
4/29/2022
In this article we review how particulate removal through filtration effects column life and how to handle difficult to filter samples.
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Nucleases - Are They A Problem For NAB NanosepĀ® Centrifugal Devices?
4/29/2022
We examine whether the sample tubes and collection tubes of the NAB Nanosep centrifugal devices contain detectable amounts of DNase or RNase.
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How High-Performance Syringe Filters Extend The Life Of Analytic Instruments And Columns
4/28/2022
This scientific brief reviews how high-performance syringe filters protect and extend the life of analytical HPLC and UHPLC instruments and columns.
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DNA Purification From PCR Or Agarose Gels
4/28/2022
This study assesses the use of NAB Nanosep centrifugal devices with commercially available reagents for PCR or agarose gel cleanup.