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Expanding SPR Uses In Antibody Effector Function Determination
2/25/2020
SPR can be implemented at early stages in screening and testing strategies in order to provide better, faster and stronger analysis of drug candidates. In this webinar we demonstrate in order to minimize risk and to get “true” affinity in binding analysis we have adopted the latest innovation in surface plasmon resonance, SPR, technology, Biacore™ 8K, to develop and qualify assays for monoclonal antibodies and other therapeutic proteins to ensure all critical quality attributes are set and controlled with accuracy and precision.
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Novel Analytics To Improve Bioprocessing And Validation Guideline Review
2/25/2020
A thorough understanding of how the process impacts the product quality attributes is essential for decision-making. Implementation of a robust analytical control strategy with information-rich technologies has the potential to significantly improve characterization and productivity. This presentation will provide an overview of how innovative protein analysis tools have been adopted for better comparability, release testing, and impurity monitoring.
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Unifying Cell Therapy Logistics And Manufacturing
2/24/2020
The supply chain and logistics for cell and gene therapies are especially critical to ensure the right patient gets the right treatment at the right time. Collaboration is the key to solving challenges such as data management and process variability, as stakeholders work towards a common goal—getting these life-saving treatments to the people who need them.
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Controlled Endpoint In Cryopreservation
2/24/2020
Successful cryopreservation of cells requires a controlled cooling rate. Cooling too rapidly or too slowly could lead to a poorer outcome. This application note demonstrates how controlled-rate cooling is achieved using equipment such as VIA Freeze controlled-rate freezers.
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The Effect Of Rocking Rate And Angle On T Cell Cultures Grown In Expansion Systems
2/23/2020
Ensuring optimal and maximal T cell production is critical for adoptive immunotherapy and its continued success. The Xuri Cell Expansion System is an important component of the clinical manufacturing process so we sought to investigate the effect of the rocking rate and angle on the expansion of T cells.
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Scale-Up Of CHO Cell Fed-Batch Cultures In HyClone™ ActiPro™ Medium Supplemented With Cell Boost™ 7a And 7b
2/21/2020
The most widely used cell lines for biopharmaceutical production of therapeutic proteins originate from CHO cells. These cells are robust in culture and are able to produce a variety of recombinant glycoproteins at high levels in large scales. This application note compares cell growth and recombinant protein production of multiple Chinese hamster ovary (CHO) cell clones when cultured in HyClone ActiPro basal medium and Cell Boost 7a and 7b feeding supplements.
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Effects Of Feeding Strategy On CHO Cell Performance In Fed-Batch Cultures Using HyClone™ ActiPro™ Medium And Cell Boost™ 7a And 7b Supplements
2/21/2020
ActiPro cell culture production medium is intended to be used in combination with Cell Boost 7a and 7b supplements to enhance recombinant protein production in fed-batch or perfusion processes. This work demonstrates the development of a fed-batch process for a CHO cell line producing a monoclonal antibody (mAb). The results emphasize the importance of an appropriate feeding strategy to achieve optimal cell growth and productivity.
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Cell Culture Titer & Protein Quality
2/21/2020
When evaluating media with the goal of increasing titers, it is important to ensure that protein quality is not negatively impacted. So how can this process improvement be performed reliably? It makes sense to use a Design of Experiment (DoE) and empirical approach. Here is an example of how to do it.
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Evaluating The Economics Of Today’s Biomanufacturing Strategies: Can You Afford The Cost Of Failure?
2/21/2020
Prior to making critical decisions about its strategy, a small biotech company completed an economic evaluation of different manufacturing options to ensure it was selecting the one that best fit its drug development needs.
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Chronicle™ Automation Software
2/18/2020
Chronicle automation software is a fit-for-purpose digital solution designed to optimize complex cell therapy process development and manufacturing. It provides a unified digital platform to monitor your facility manufacturing operations and supply chain logistics.