Altasciences Featured Articles

  1. Reducing The Number Of Animals In Toxicity Testing: Comparing Rodent, Large Animal Studies 2/4/2025

    Learn how our refined study designs and innovative blood microsampling techniques can reduce animal use in toxicity studies.

  2. Development Of A Flow Cytometry Phospho-STAT5 Assay In Nonhuman Primate T Cells 2/4/2025

    Discover how our flow cytometry-based pSTAT5 assay in Macaca fascicularis can enhance toxicological studies by providing precise, high-throughput analysis of T cell activation.

  3. Development Of A Novel Canine Prostatectomy Model 2/4/2025

    See how our refined canine partial prostatectomy model offers a promising approach for studying prostate cancer treatments and testing locally applied therapies.

  4. Proposed Best Practices For Optimizing The Number Of Animals In Toxicology Studies 2/4/2025

    The emergence of new drug modalities, coupled with the limited availability of certain research animal models, underscores the need for continuous evaluation of study designs and technologies that support the reduction of animal use in toxicology studies.

  5. Overcoming The Challenges In The Use Of Vascular Access Buttons™ In Rodents 2/4/2025

    Explore how refinements in vascular access button implementation can enhance catheter patency, reduce complications, and improve data quality in preclinical rodent studies.

  6. Historical Review Of In-Life Data From Studies Utilizing AAVs For Gene Therapy 2/4/2025

    These findings provide valuable insights for optimizing AAV study designs while identifying opportunities to refine and reduce the use of NHPs in preclinical research.

  7. Creation Of A Swine Model Of Oral Angioedema 2/4/2025

    Discover how our novel large animal model for angioedema can advance treatment evaluation and drug absorption studies.

  8. Comparison Of Cardiovascular And Respiratory Parameters In 3 Strains Of Research Pigs 2/4/2025

    In this study, cardiovascular and respiratory parameters of Sinclair Nanopigs™ were compared to those of Göttingen® and Yucatan™ minipigs (n=62, average weight 19±6 kg, age 6.5 months).

  9. Understanding Species Variation In The Occurrence Of Spontaneous Background Eye Lesions 2/4/2025

    To better understand the prevalence of naturally occurring ocular lesions, we reviewed acclimation and pre-test data collected over the past year from rats, mice, NHPs, and dogs at our facility.

  10. Introducing Philippine-Origin Cynomolgus Macaque As A Model In Safety Assessments 2/4/2025

    Supply shortages and rising demand for cynomolgus macaques (Macaca fascicularis) in (bio)therapeutic drug development have led to increased reliance on animals sourced from various regions.