Altasciences Featured Articles

  1. Incidence Of Neutralizing Adeno-Associated Viral Antibody Subtypes In Cynomolgus Monkeys 1/8/2025

    Ensure thorough screening for pre-existing antibodies against specific AAV serotypes when initiating preclinical safety studies for AAV-based gene therapies to optimize animal selection and study design.

  2. T-Cell-Dependent Antibody Responses And Immunopathology 1/8/2025

    Leverage historical NHP data from diverse origins to improve safety assessments for emerging therapies targeting rare diseases.

  3. Qualification Of A Veterinary Glucometer For Use In Yucatan Miniature Swine 1/8/2025

    Identify and implement a glucometer calibrated for swine to enable accurate real-time blood glucose monitoring in both diabetic and non-diabetic Yucatan swine for research purposes.

  4. Examining The Effects Of Body Temperature On QT Interval In Non-Naïve Telemetered Göttingen Minipig 1/8/2025

    Learn to develop and apply a QTcH correction formula incorporating body temperature changes (QTcHcT) for more accurate cardiac assessments in both conscious and anesthetized Göttingen Minipigs®.

  5. Immunomodulatory Approaches In Preclinical Gene Therapy Studies 1/8/2025

    Utilize insights from recent data on premedication regimens to optimize gene therapy study designs and enhance clinical translation by minimizing immune responses in nonhuman primates.

  6. Intra-Cerebroventricular (ICV) Route In Mice For Administrating Gene Therapy Products 1/8/2025

    Optimize analgesic protocols for intracerebroventricular (ICV) administration in preclinical studies to enhance behavioral assessments and fully realize the potential of gene therapy for treating CNS disorders.

  7. Intravenous Sampling And Administration Using InstechVascular Access Buttons In Rodents 1/7/2025

    For reliable and efficient preclinical safety assessments, consider utilizing Vascular Access Buttons (VABs) for repeated intravenous administrations, ensuring accurate results while minimizing complications in rodent models.

  8. Leveraging Nonclinical Safety Findings To Expedite Next-Generation GLP-1RAs Development 1/7/2025

    Leverage our in-depth analysis of FDA-approved GLP-1RA therapies to identify potential safety concerns and expedite the development of transformative GLP-1RA therapies in early-stage development.

  9. Lipid Nanoparticles: A Comprehensive Assessment Of Liver Enzymes And Immunopathology Markers In Nonhuman Primates 1/7/2025

    Through robust preclinical studies, see how we were able to bridge knowledge gaps and ensure regulatory compliance, thus enhancing the safety and efficacy of lipid nanoparticles.

  10. Comparison Of Safety Pharmacology End Points Used On Toxicology Studies Across Differing Cynomolgus Monkey Origins 1/7/2025

    Leverage robust safety pharmacology data from diverse cynomolgus macaque populations to enhance the accuracy and reliability of your biotherapeutic toxicology studies.