Altasciences Featured Articles

31. Characterization Of Normal Skin Thickness For Various Body Regions, Ages, And Genders Of Yucatan Miniature Swine 2/11/2025

    This study provides valuable data on the skin thickness of Yucatan miniature swine, offering essential insights for researchers in dermatology and drug absorption studies, ultimately advancing the understanding of porcine skin for biomedical research.

32. Utilizing Traditional Versus Modified Methods For Surgical Closing And Post-Operative Treatment For Muscle Biopsy Sites 2/11/2025

    By implementing modifications to muscle biopsy procedures, including improved closure techniques and post-operative care, we significantly reduced post-operative complications and eliminated confounding variables, enhancing the reliability of toxicology studies in nonhuman primates.

33. Establishment Of An Induced Hemophilia A Model In Anesthetized Cynomolgus Monkeys 2/11/2025

    The induction of hemophilia A in cynomolgus monkeys using sheep anti-FVIII successfully models the disorder, demonstrating significant perturbations in coagulation and bleeding parameters.

34. In Vivo And Histological Analysis Of Focal Chorioretinal Defects In Dutch Belted Rabbits 2/11/2025

    The goal of our study is to explore the in vivo retinal microanatomy in Dutch Belted laboratory rabbits, specifically examining findings observed during pretest ophthalmic examinations.

35. Correlating Changes In Body Weights And Immune System Parameters 2/11/2025

    To improve the assessment of drug-related immune system impacts, our study demonstrates that body weight does not influence circulating immune cell populations in cynomolgus macaques.

36. Downsized Sinclair Vs. Göttingen; Minipigs Similarities And Differences Of Toxicological Reference Range Data 2/11/2025

    To optimize breed selection in nonclinical toxicology studies, our analysis compares baseline toxicological data between Sinclair™ and Göttingen™ minipigs, providing crucial insights for informed drug development decisions.

37. Comparison Of Toxicology Assessment Baseline Data Collected Using 2 Restraint Methods In Nonhuman Primates 2/11/2025

    This study aimed to compare the impact of these restraint methods on toxicological assessments in NHP studies and provide evidence-based recommendations for best practices in laboratory restraint techniques.

38. Gene Therapy Utilizing AAV Vectors: Historical Data Review To Characterize Common Challenges And Identify Opportunities For Refinement 2/11/2025

    Our analysis of 22 toxicology studies provides key insights to optimize AAV vector safety assessments, streamline nAb screening, and refine corticosteroid pretreatment — helping to improve study design while reducing and refining animal use.

39. Reducing The Number Of Animals In Toxicity Testing: Comparing Rodent, Large Animal Studies 2/4/2025

    Learn how our refined study designs and innovative blood microsampling techniques can reduce animal use in toxicity studies.

40. Development Of A Flow Cytometry Phospho-STAT5 Assay In Nonhuman Primate T Cells 2/4/2025

    Discover how our flow cytometry-based pSTAT5 assay in Macaca fascicularis can enhance toxicological studies by providing precise, high-throughput analysis of T cell activation.