Altasciences Featured Articles

31. In Vivo And Histological Analysis Of Focal Chorioretinal Defects In Dutch Belted Rabbits 2/11/2025

    The goal of our study is to explore the in vivo retinal microanatomy in Dutch Belted laboratory rabbits, specifically examining findings observed during pretest ophthalmic examinations.

32. Correlating Changes In Body Weights And Immune System Parameters 2/11/2025

    To improve the assessment of drug-related immune system impacts, our study demonstrates that body weight does not influence circulating immune cell populations in cynomolgus macaques.

33. Downsized Sinclair Vs. Göttingen; Minipigs Similarities And Differences Of Toxicological Reference Range Data 2/11/2025

    To optimize breed selection in nonclinical toxicology studies, our analysis compares baseline toxicological data between Sinclair™ and Göttingen™ minipigs, providing crucial insights for informed drug development decisions.

34. Comparison Of Toxicology Assessment Baseline Data Collected Using 2 Restraint Methods In Nonhuman Primates 2/11/2025

    This study aimed to compare the impact of these restraint methods on toxicological assessments in NHP studies and provide evidence-based recommendations for best practices in laboratory restraint techniques.

35. Gene Therapy Utilizing AAV Vectors: Historical Data Review To Characterize Common Challenges And Identify Opportunities For Refinement 2/11/2025

    Our analysis of 22 toxicology studies provides key insights to optimize AAV vector safety assessments, streamline nAb screening, and refine corticosteroid pretreatment — helping to improve study design while reducing and refining animal use.

36. Reducing The Number Of Animals In Toxicity Testing: Comparing Rodent, Large Animal Studies 2/4/2025

    Learn how our refined study designs and innovative blood microsampling techniques can reduce animal use in toxicity studies.

37. Development Of A Flow Cytometry Phospho-STAT5 Assay In Nonhuman Primate T Cells 2/4/2025

    Discover how our flow cytometry-based pSTAT5 assay in Macaca fascicularis can enhance toxicological studies by providing precise, high-throughput analysis of T cell activation.

38. Development Of A Novel Canine Prostatectomy Model 2/4/2025

    See how our refined canine partial prostatectomy model offers a promising approach for studying prostate cancer treatments and testing locally applied therapies.

39. Proposed Best Practices For Optimizing The Number Of Animals In Toxicology Studies 2/4/2025

    The emergence of new drug modalities, coupled with the limited availability of certain research animal models, underscores the need for continuous evaluation of study designs and technologies that support the reduction of animal use in toxicology studies.

40. Overcoming The Challenges In The Use Of Vascular Access Buttons™ In Rodents 2/4/2025

    Explore how refinements in vascular access button implementation can enhance catheter patency, reduce complications, and improve data quality in preclinical rodent studies.