Altasciences Featured Articles

  1. Development Of An IL-31-Induced Pruritus Model In Cynomolgus Monkeys 2/25/2025

    Explore the potential of the cynomolgus monkey model with IL-31 pruritus to advance research and development of effective treatments for atopic dermatitis and other pruritic skin diseases.

  2. Use Of Thromboelastography (TEG) In Preclinical Studies 2/25/2025

    Leverage TEG alongside conventional hematology to enhance the evaluation of coagulation disorders and provide more comprehensive insights into drug development and bleeding disorders.

  3. LC-MS/MS Determination Of Pirfenidone And Metabolites In Rat Plasma 2/25/2025

    Explore the feasibility and efficiency of using a single assay coupled with LC-MS/MS for quantifying Pirfenidone and its metabolites in rat plasma, ensuring precision, accuracy, and separation.

  4. Assessment Of Subcutaneous Radio-Telemetry Device Implantation 2/25/2025

    Consider the potential of subcutaneous telemetry implants as a less invasive, effective alternative to intra-abdominal implants, ensuring high-quality data while reducing surgical trauma.

  5. Historical Control Database Of Cynomolgus Macaque Spermatozoa 2/25/2025

    Understand why establishing robust criteria for normal cynomolgus macaque sperm is essential for accurate interpretation of pharmaceutical effects on male reproductive health.

  6. Snuggle Wrap-Based Restraint Method For Continuous Infusion In Juvenile Nonhuman Primates 2/25/2025

    This innovative "snuggle method" offers a stress-reducing, effective alternative to traditional restraint techniques in pediatric primate studies, ensuring comfort and reliable data collection.

  7. Surgical Closure Method For Muscle Biopsy Sites In Group-Housed NHPs 2/25/2025

    Implementing enhanced surgical procedures, including the use of surgical staples and ceftiofur, can significantly reduce postoperative complications and allow for quicker return to group housing.

  8. Preclinical Strategies In Rodent Studies Using VAMS® 2/25/2025

    Blood microsampling techniques, such as Volumetric Absorptive Microsampling (VAMS®), can be used to reduce animal use, refine experimental designs, and improve ethical practices.

  9. Cytokine Data Evaluation In NHP Safety Studies: Correlation To Toxicity Outcomes 2/25/2025

    This cytokine data in conjunction with other clinical findings was used to improve the accuracy of toxicity assessments, the timing of measurements, and the specific cytokines involved.

  10. Historical Control Reference Values for Cambodian Cynomolgus Macaque Blood Gases 2/25/2025

    Utilize the provided baseline blood gas data for cynomolgus macaques to enhance the assessment of drug-related respiratory effects and improve the accuracy of respiratory safety evaluations.