Newsletter | September 8, 2026

09.08.26 -- Which Discovery Technologies Help Solve Degrader Assay Gaps

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Unlocking Challenging Targets with Macrocycle DNA-Encoded Libraries

What if the next breakthrough target requires more than a conventional small molecule? Explore how macrocycle DNA-encoded libraries are opening new paths to challenging drug targets. This X-CHEM webinar will reveal how macrocycles expand chemical space, uncover differentiated hits, and generate insights that can accelerate discovery. Learn where macrocycle DELs can make the biggest impact and how they could reshape your strategy. Click here to learn more.

FEATURED EDITORIAL

Which Discovery Technologies Help Solve Degrader Assay Gaps

Johannes Yeh says degrader discovery requires robust screening systems to measure target engagement, ternary complex formation, stability, and degradation, supported by tools such as CRISPR, shRNA, and proteomics.

 

Aligning Standards, Validation, And Governance For Digital Preclinical Research

By Stefano Gaburro, CSO, and Szczepan W. Baran, CEO, Digital Preclinical Society

No single body integrates preclinical data components into a coherent discipline supported by shared standards, common terminology, and collective accountability.

Beyond Engineered Antibodies: Harnessing The Natural Human Repertoire

A conversation with Srikanth Pendyala, MD, chief medical officer, Infinimmune

We caught up Srikanth Pendyala, MD, CMO of Infinimmune, to discuss the importance of learning directly from the human immune system itself in antibody research.

INDUSTRY INSIGHTS

 

Covalent Warhead Reactivity: A New Look At GSH Reactivity Assays

Application Note | By Stéphane Turcotte, X-Chem

Understanding covalent warhead kinetics is key to reducing safety risks early in discovery. Learn about a new approach to GSH‑based measurements that offers clearer predictors of toxicity.

 

How To Deal With The Complexity Of Drugs In Clinical Development

Article | Lonza

The increasing complexity of the drugs currently in clinical development has created mounting pressure for companies hoping to surmount the myriad challenges that typify these therapeutic modalities.

 

Spatial Organization Of The CAR Is Critical For CAR T Cell Function

Application Note | BD Biosciences

Explore how advanced single‑cell analysis links CAR localization, cell structure, and functional behavior, offering deeper insight into CAR T cell heterogeneity and performance.

 

Streamlined Selection Of In Vivo Predictive Dissolution Media

Webinar | Lonza

Examine the design of dissolution media to support biopredictive dissolution testing and a method for selecting practical, physiologically relevant media based on drug, formulation, and GI fluid properties.

 

Accelerating Cell Therapy Discovery With High-Throughput Electroporation

Application Note | MaxCyte, Inc.

Discover how high-throughput electroporation-based screening can compress your CAR-T optimization timeline while delivering reproducible, scale-ready results across multiple donor samples.

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The Festival of Biologics Basel is Europe's largest biologics event, covering the start-to-finish of the industry in antibody therapies, cell and gene therapies, immunotherapies and biosimilars. Designed for industry experts in pharma and biotech, start-ups, academics, regulators and investors, the Festival of Biologics is the meeting place for the large molecule therapy ecosystem, bringing together 3000+ attendees. Use the code LSC20 for 20% off. Book your ticket now

SOLUTIONS

Calculate Physicochemical Properties

Revvity Signals Software, Inc.

Efficient High Throughput scNMT Profiling

INTEGRA Biosciences