Which Discovery Technologies Help Solve Degrader Assay Gaps

Johannes Yeh says degrader discovery requires robust screening systems to measure target engagement, ternary complex formation, stability, and degradation, supported by tools such as CRISPR, shRNA, and proteomics. Maria Soloveychik adds that her company built a cell-based platform to test induced proximity and degradation intracellularly, using viability as a functional readout before confirming hits with biophysical assays, genomics, mutagenesis, and SAR.