|
|
|
|
If you’re working on degraders in 2025, simply knowing what a PROTAC is isn’t enough. From AI-guided design to subcellular PK profiling, researchers are rethinking how they define, measure, and optimize every step of the degradation process. Here are 10 essential and evolved terms to keep you ahead of the curve.
|
|
|
|
|
For effective proximity therapeutics like PROTACs, optimizing cooperativity is key. Dr. Hans-Jörg Roth, former Novartis director, explains how enhancing stabilizing interactions can reduce molecular size while maintaining potency.
|
|
|
|
|
As a scientist working in PROTAC development, you’re tasked with finding a therapy for challenging targets that aim to address intractable diseases such as cancer. Here are four important questions to ask yourself in your PROTAC development process to ensure you’re building an effective protein degrader and using the right tools at each step.
|
|
|
|
|
Characterizing the PROTAC hook effect is crucial for selecting candidates with enhanced cooperativity. Gain confidence with flexible, in-solution affinity measurements that reveal key biophysical parameters and align with established three-component binding models.
|
|
|
