10 Evolved Terms Every Scientist Should Know About Targeted Protein Degradation In 2025

Targeted Protein Degradation (TPD) has rapidly evolved into a cornerstone of modern drug discovery. The terminology used in this dynamic field is also advancing, reflecting sophisticated new approaches to defining, measuring, and optimizing the degradation process. For instance, understanding ternary complexes now involves analyzing their residence time and cooperativity, not just their formation. Similarly, the hook effect, once a challenge, is now managed through advanced simulations guiding linker design.

New classes of degraders like LYTACs, AUTACs, and ATTECs are expanding TPD's reach beyond the proteasome by directing proteins to lysosomes or autophagosomes. Researchers are also strategically selecting E3 ligases based on tissue expression or disease specificity, and leveraging cutting-edge tools like AI-guided design to predict degrader structures and activities, significantly accelerating development. Dive deeper into these and other essential terms to stay at the forefront of TPD research.