Newsletter | April 7, 2026

04.07.26 -- What If The U.S. Government Stopped Funding Biotech?

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Drug discovery is shifting from traditional hit identification toward data-driven strategies that extract deeper insight from large-scale screening datasets. Advances in DNA-encoded library (DEL) screening, computational tools, and machine learning are helping teams make more informed decisions in early-stage drug development. Access this brand-new Drug Discovery Online content collection for an under-the-hood look at modern approaches to turning large discovery datasets into actionable insight.

FEATURED EDITORIAL

What If The U.S. Government Stopped Funding Biotech?

It sets off a real tension – ideological, economic, even personal. But what would happen if the U.S. government cut direct financial support for “biotechnology research,” leaving it entirely to investors, private and public markets, and bigger pharma?

Proteomics Tools: A Resurrection

For decades, the evolution of proteomics has lagged. Now, a resurrection is underway. New tools are dismantling limitations, signifying a maturation of systems biology.

Rethinking Disease Modification Through Targeted Immunotherapy

As understanding of immune-driven disease deepens, therapies that selectively correct dysregulated inflammation have the potential to reshape treatment paradigms.

INDUSTRY INSIGHTS

Drug Discovery Beyond Rule Of Five: ECCS Class 3 And 4 Strategies

Gain practical guidance for advancing bRo5 candidates through improved permeability and metabolic stability with insights on ECCS classes 3 and 4, optimized in vitro tools, and design principles.

Towards A More Predictive Model Of Human Biology: A Fireside Chat

Explore the implications of the FDA Modernization Act 2.0, the significance of predictive validity in drug discovery, the efficacy of an innovative human Liver-Chip, and more.

Identify And Mitigate Absorption Risks With PBPK Modeling

See how PBPK models combined with custom and off-the-shelf in vitro tools and solubility enhancement expertise can reduce the need for drug product reformulation or repeated preclinical or clinical studies.

Automated Library Prep For A Nanopore DNA Barcoding Protocol

A streamlined workflow reduces reagent use and hands‑on time while preserving long‑read sequencing quality. Find out how multiplexed offer an efficient option for scaling or mobilizing sequencing efforts.

Mastering Spectral Flow Cytometry: Foundational Concepts And Techniques

Discover how spectral flow cytometry enhances flexibility and resolution in high-parameter experiments. Gain practical insights on panel design, fluorochrome selection, and control strategies.

From Powder To Particles With Jet Milling

Learn more about the jet milling process and Quality by Design approach for inhalation drug delivery and their potential applications in drug development.

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With 1900+ attendees, TIDES USA, May 11-14, 2026, at Boston's Hynes Convention Center, is North America's leading forum for advancing oligonucleotide, peptide, mRNA, genome editing, and delivery innovations. This event bridges research to reality, fostering collaboration, and breakthrough solutions. Explore cutting-edge workshops, tracks, and exhibits while connecting with global pioneers like Robert Langer and Kiran Musunuru. Register early for any early bird savings and save an additional 10% with VIP code ADVRNA10 at checkout!