08.12.25 -- The Rise Of NAMs

A panel of product development experts examines blind spots that can plague early development strategies, as well as important considerations when navigating the path toward an IND submission.

Learn about a novel cell-based assay that can advance ubiquitin ligase drug discovery. This high-throughput method simplifies assay development, saving time and resources.

Discover how an innovative technology harnesses natural RNA editing with EONs and digital PCR to precisely correct mutations, which offers a novel approach to treating genetic diseases.

Targeted Protein Degradation is a core drug discovery strategy. Evolving terminology, from ternary complex dynamics to AI-guided design, is essential for scientists to navigate this advancing field in 2025.

Review the optimization of the manufacturing process of a pharmaceutical intermediate, and discover how yield can be improved substantially via suitable reaction engineering.

Explore how lipid nanoparticles are revolutionizing non-viral gene editing with scalable, efficient delivery for both ex vivo and in vivo applications, which features new CRISPR-LNP data in T cells.

See how an amorphous solid dispersion (ASD) of acalabrutinib was designed using in vitro studies and in silico modeling. Understand how ASD formulations can enhance bioavailability.