Newsletter | December 16, 2025

12.16.25 -- Returning To Nature: Discovering The Next Generation Of Medicines

FEATURED EDITORIAL

2025's Top 5 Drug Discovery Highlights And How To Stay Ahead In 2026

Drug Discovery Online's 2025 Top 5 most consequential shifts affecting this rapidly evolving field, including NAMs, AI, Individualized Therapies, Innovating China, and Early-stage Funding Volatility.

Returning To Nature: Discovering The Next Generation Of Medicines

Researchers at Kapoose Creek Bio are looking to use nature, specifically fungi, to treat mental health and neurodegenerative disorders.

Protein Degraders Redefine ADME And Drug Disposition Dynamics

ADME principles have been recently challenged by the emergence of protein degraders, or proteolysis-targeting chimeras (PROTACs), which can benefit from an ABDE framework instead.

INDUSTRY INSIGHTS

Lung Cancer Treatment By Inhaled Formulations

Explore the formulation and manufacturing of a topotecan inhaled dry powder and its use in decreasing tumor size in an animal model.

Multicolor Flow Cytometry Panel Design

Watch a series of videos on multicolor flow cytometry panel design to gain a comprehensive understanding, as well as various strategies to streamline panel design.

Calu-6 Human Non-Small Cell Lung Adenocarcinoma Model

See a validated preclinical model for non-small cell lung cancer that features KRAS mutation and TP53 inactivation. The system is essential for studying therapeutic drug resistance mechanisms.

Liquid Phase Peptide Synthesis: Regulatory, Analytical, And QC Perspectives

Discover how Liquid Phase Peptide Synthesis (LPPS) uses traditional reactors to create more efficient and sustainable peptide manufacturing. Learn about key analytical and quality control considerations.

Innovative Surgical Solutions: Safety Assessment Studies

Delve into the innovative techniques our surgical experts use to support toxicology and safety pharmacology studies, including dose development and procedures.

Reducing Risk, Decreasing Timelines, And Optimizing Outcomes

Uncover the challenges of cell line development (CLD) in biologics commercialization and discover how integrated solutions can streamline your strategy, reduce risks, and optimize outcomes.

New Technologies To Improve Solubility Of Brick Dust Compounds

David Lyon, Ph.D., and Molly Adam answer attendee questions from a recent webinar about three enabling technologies designed to improve drug solubility in organic solvents for spray drying.

SOLUTIONS

Discover A Platform For Antibodies With Increased ADCC Activity

Fragment Screening: Save Time And Sample With Spectral Shift Technology

PBPK Predictive Modeling Services