PBPK Predictive Modeling Services

Early identification of potential absorption risks, such as poor solubility, dissolution, and/or permeability, is critical for rapid and efficient drug development. Upfront knowledge of absorption risks can trigger early assessment of solid form and formulation strategies designed to achieve target bioperformance. Lonza's dedicated Physiologically-Based Pharmacokinetic (PBPK) modeling experts work with your compound to:

• Identify absorption risks such as solubility, dissolution rate, and permeability
• Forecast fraction absorbed in preclinical and clinical species over a range of doses
• Predict the likelihood of food-drug or pH-dependent drug-drug interactions

Lonza's PBPK modeling services are designed to de-risk your drug development program. Using established ADMET Predictor® and GastroPlus® modeling software, linked with an expansive set of in-vitro testing, we can identify absorption risks and select technologies to meet target bioperformance.