Newsletter | September 19, 2023

09.19.23 -- Protein Degraders: Progress, Limitations, & Future Directions


Protein Degraders: Progress, Limitations, And Future Directions

There is great excitement surrounding the development of small molecules that trigger the degradation of proteins. This article will highlight proteolysis targeting chimeras (PROTACs), their current limitations, and the emerging strategies to address those limitations, resulting in a bright future for targeted protein degradation.

FDA Finalizes Guidance On Nonclinical Evaluation Of Pharmaceutical Immunotoxicity

The FDA has now finalized a guidance document on the immunotoxic potential of pharmaceuticals. The FDA builds on current ICH guidance and proposes a two-stage approach. Central to the guidance is using a risk framework.


Prioritize Solvent Recycling And Recovery To Realize Your Green Goals

Building more sustainable practices across the pharmaceutical industry takes a collaborative and transparent effort. One leading CDMO is leveraging their solvent recovery efforts to yield major strides.

Design Of Experiments Approach To Enabling Studies For Process Validation

A recent project applied process improvement methodology to the process validation step that ultimately provided not only an optimized, robust process but also an economic advantage.

Unexpected SEC Results: Can They Be Improved?

Sometimes, your size exclusion chromatography (SEC) results don’t look the way you want them to. Learn how to fix issues such as poor resolution, peak tailing, and fronting from the tips shared in this FAQ.

Nanoscale Technology's Potential: A Fireside Chat With Industry Leaders

Nanoform CEO Edward Haeggstrom, and Shawn Davies, head of drug delivery, biopharmaceuticals development, AstraZeneca, discuss the potential of nanoscale medicines and delivery devices.

Challenges Associated With In-Use Simulated Administration Of Biologics

Explore some of the more challenging aspects surrounding in-use testing for parenteral delivery, along with potential strategies to address these issues.


Researchers Discover Genes Behind Antibiotic Resistance In Deadly Superbug Infections

Zuberitamab Has Been Approved For Marketing In China

Verge Genomics Announces Artificial Intelligence-Enabled Drug Discovery Collaboration

Biosyngen Received FDA Approval For Phase I/II Clinical Trials For BRL03

CyGenica Limited Secures USFDA Approval For ODD For Novel Drug Conjugate In GBM Treatment

ANI Pharmaceuticals Announces The FDA Approval And Launch Of Estradiol Tablets USP

Salipro Biotech Enters Into Research Collab With Sumitomo Pharma

Navigate BioPharma Services, Inc. Collaborates With BD (Becton, Dickinson & Company)

Exelixis & Insilico Enter Into Exclusive Global License Agreement For ISM3091

Herophilus Announces Strategic Transaction With Genentech

UArizona Cancer Center Researchers Discover Iron-Targeting Approaches To Halt Proliferation Of Cancer Cells


Solid Form Services

Environmentally Controlled Stability Storage And Testing Solutions

Capacity Update March 2023: Small Molecule


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