Unexpected SEC Results – Can It Be Improved?

Source: Cytiva

By Jon Lundqvist, Scientist at Cytiva


Sometimes your size exclusion chromatography (SEC) results don’t look like you want them to. Fix issues like poor resolution, peak tailing and fronting with the tips in this FAQ.

  • How can I optimize the running conditions to optimize resolution in my SEC runs?
  • What causes peak tailing?
  • What causes peak fronting?
  • I do not get the resolution I need with my SEC column. What to do?


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