Newsletter | November 11, 2025

11.11.25 -- OpenFold3 Redefining The Limits Of Protein Prediction Models

FEATURED EDITORIAL

OpenFold3 Released: Redefining The Limits Of Protein Prediction Models

OpenFold3, a biomolecular structure prediction model based on AlphaFold3 was recently released by the OpenFold Consortium, a non-profit AI R&D organization.

Expanding A Single Mechanism Through Genetic Logic And Clinical Observation

With the right biology, a single mechanism can open multiple clinically meaningful avenues for oncology drug development. Step Pharma CEO discusses their clinical development programs for oncology.

INDUSTRY INSIGHTS

Driving Sustainability In Spray Drying Through Enabling Technologies

By transitioning to alternative solvents or leveraging process aids, the challenges associated with the use of these chemicals can be addressed, helping create a sustainable, greener footprint.

Leveraging AI And ML For Better Biologics

For many bioprocessing applications, artificial intelligence (AI) and machine learning (ML) can be used in every phase of development to support optimization and streamline repetitive, effort-intensive processes.

Advancing Cell Therapies With Lipid Nanoparticles

Cell therapies, using reprogrammed immune cells, offer treatments for diseases. Discover how LNPs enhance these therapies by delivering RNA for gene modulation and next-gen treatments.

Liquid Phase Peptide Synthesis: Regulatory, Analytical, And QC Perspectives

See how Liquid Phase Peptide Synthesis (LPPS) uses traditional reactors to create more efficient and sustainable peptide manufacturing. Learn about key analytical and quality control considerations.

Designing IND-Enabling Toxicity Studies For Complex Drug Modalities

Traditional toxicity studies don’t always fit today’s complex drug modalities. Watch as experts discuss how we’re adapting small molecule IND-enabling studies to meet modern therapeutic challenges.

Process Re-Design For Sustainability In Small Molecule Manufacturing

Review the optimization of the manufacturing process of a pharmaceutical intermediate, and uncover how yield can be improved substantially via suitable reaction engineering.

Rapid Production Of Assay Ready Cells For GPCR Drug Discovery

Accelerate drug discovery by leveraging transiently transfected assay-ready cells. This method improves assay sensitivity and reduces variability for GPCRs.

PROTAC Hook Effect With Flexible In-Solution Affinity Measurements

Characterizing the PROTAC hook effect is crucial for selecting candidates with enhanced cooperativity. Gain confidence with flexible, in-solution affinity measurements that reveal key biophysical parameters.

Expand Your Capabilities And Shorten Your Time-To-Clinic

Gain expert insights into cell line development for biologics commercialization. and learn how CLD services—from DNA to GMP Master Cell Bank—can accelerate your path to clinical success.

SOLUTIONS

Solid Form Services

Delivering Global ADC Development Solutions

Streamline Your Lab Workflow Through Flexibility And Automation