Modeling Inflammation-Specific Immune Cell Recruitment In The Colon Intestine-Chip

Inflammatory bowel disease (IBD) is a complex pathology with a large and rapidly growing unmet medical need. Traditional methods for studying IBD, such as animals and conventional in vitro models, fall short due to their limited relevance to human physiology, narrow scope of disease representation, and a variety of other issues that hinder the development of effective IBD therapeutics.

Emulate’s Colon Intestine-Chip was developed as a primary human vascularized model of the intestinal barrier recapitulating physiologic cell composition, morphology, and barrier function. In this application, the Colon Intestine-Chip is used to model the progression of IBD driven by immune cells, demonstrating it is more accurate than previous models.