MabSelect™ VL Affinity Resin

MabSelect™ VL affinity resin uses a protein L ligand with strong affinity for the variable region of a human antibody’s kappa light chain. The resin offers high productivity and robust processes for affinity capture of bispecific antibodies and antibody fragments containing the kappa light chain and offers a good capture alternative for antibody variants that do not bind to protein A. This resin has substantially improved dynamic binding capacity (DBC) and alkaline stability compared to its predecessor, making it well-suited for cost-efficient capture of antibody variants. MabSelect™ VL resin allows for good resolution of product-related impurities in the capture of bispecific antibodies, and it provides a tool for efficient purification of antibody variants to high purity.